Sakai Toshiro, Sato Ken, Kikuchi Tomoki, Obata Masahiko, Konuma Yuichi
Department of Hematology and Oncology, Asahikawa Red Cross Hospital, Japan.
Intern Med. 2020;59(2):261-266. doi: 10.2169/internalmedicine.3314-19. Epub 2020 Jan 15.
Mucormycosis has emerged as the third-most common fungal mycosis and is one of the most fatal molds. We herein report a case study of a 30-year-old woman who was a veterinarian, specializing in livestock, who developed disseminated mucormycosis during induction therapy for acute lymphoblastic leukemia. We successfully used a radical approach for treatment, including a surgical procedure and allogeneic transplantation, with continuous administration of antifungal agents. Reports of successful treatments are extremely rare, and our case has had the longest documented remission from disseminated disease. We speculate that our case's occupational environment may represent a risk factor for development of mucormycosis.
毛霉病已成为第三常见的真菌性霉菌感染，也是最致命的霉菌之一。我们在此报告一例病例研究，患者为一名30岁的女性兽医，专长于家畜医学，在急性淋巴细胞白血病诱导治疗期间发生了播散性毛霉病。我们成功采用了一种根治性治疗方法，包括外科手术和异基因移植，并持续给予抗真菌药物。成功治疗的报告极为罕见，我们的病例是有记录以来播散性疾病缓解期最长的。我们推测，该病例的职业环境可能是毛霉病发病的一个风险因素。
