Nadeau Kristen J, Anderson Barbara J, Berg Erika G, Chiang Jane L, Chou Hubert, Copeland Kenneth C, Hannon Tamara S, Huang Terry T-K, Lynch Jane L, Powell Jeff, Sellers Elizabeth, Tamborlane William V, Zeitler Philip
Department of Pediatrics, University of Colorado School of Medicine, and Department of Endocrinology, Children's Hospital Colorado, Aurora, CO.
Section of Psychology, Department of Pediatrics, Baylor College of Medicine Education at Texas Children's Hospital, Houston, TX.
Diabetes Care. 2016 Sep;39(9):1635-42. doi: 10.2337/dc16-1066. Epub 2016 Aug 2.
Type 2 diabetes is a significant and increasing burden in adolescents and young adults. Clear strategies for research, prevention, and treatment of the disease in these vulnerable patients are needed. Evidence suggests that type 2 diabetes in children is different not only from type 1 but also from type 2 diabetes in adults. Understanding the unique pathophysiology of type 2 diabetes in youth, as well as the risk of complications and the psychosocial impact, will enable industry, academia, funding agencies, advocacy groups, and regulators to collectively evaluate both current and future research, treatment, and prevention approaches. This Consensus Report characterizes type 2 diabetes in children, evaluates the fundamental differences between childhood and adult disease, describes the current therapeutic options, and discusses challenges to and approaches for developing new treatments.
2型糖尿病在青少年和青年中是一个日益严重的负担。需要有明确的策略来对这些易患人群进行该疾病的研究、预防和治疗。有证据表明，儿童2型糖尿病不仅与1型糖尿病不同，也与成人2型糖尿病不同。了解青少年2型糖尿病独特的病理生理学，以及并发症风险和社会心理影响，将使产业界、学术界、资助机构、倡导团体和监管机构能够共同评估当前和未来的研究、治疗及预防方法。本共识报告对儿童2型糖尿病进行了特征描述，评估了儿童与成人疾病之间的根本差异，介绍了当前的治疗选择，并讨论了开发新疗法面临的挑战和方法。
