急性心肌梗死后大鼠实验性阿伏唑治疗的延迟结果

Delayed Results of Experimental Afobazole Therapy in Rats after Acute Myocardial Infarction.

作者信息

Kryzhanovskii S A, Tsorin I B, Stolyaruk V N, Ionova E O, Vititnova M B

机构信息

V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2017 Jun;163(2):180-183. doi: 10.1007/s10517-017-3761-7. Epub 2017 Jul 18.

DOI:10.1007/s10517-017-3761-7

PMID:28726201

Abstract

Delayed cardioprotective effects of anxiolytic Afobazole (15 mg/kg, intraperitoneally for 14 days) were evaluated using dynamic echocardiographic recordings on days 2, 15, 56, and 98 after experimental myocardial infarction modeling (rat model of acute myocardial ischemia). The cardiotropic activity of Afobazole is assumed to be related to its agonistic effects on σ receptor of cardiomyocytes. It was found that animals treated with Afobazole had no signs of heart failure by the end of observation, as evidenced by left ventricular ejection fraction.

摘要

在实验性心肌梗死建模（大鼠急性心肌缺血模型）后的第2天、15天、56天和98天，使用动态超声心动图记录评估抗焦虑药阿福唑（15毫克/千克，腹腔注射，持续14天）的延迟心脏保护作用。阿福唑的心脏作用活性被认为与其对心肌细胞σ受体的激动作用有关。结果发现，到观察结束时，接受阿福唑治疗的动物没有心力衰竭的迹象，左心室射血分数证明了这一点。