阿伏唑嗪在实验性心肌梗死中的抗缺血作用研究。

Study of anti-ischemic effect of afobazole in experimental myocardial infarction.

作者信息

Kryzhanovskyi S A, Sorokina A V, Stolyaruck V N, Vititnova M B, Miroshkina I A, Tsorin I B, Durnev A D, Seredenin S B

机构信息

V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.

出版信息

Bull Exp Biol Med. 2011 Jan;150(3):316-9. doi: 10.1007/s10517-011-1131-4.

DOI:10.1007/s10517-011-1131-4

PMID:21240343

Abstract

Seven-day treatment of rats with experimental myocardial infarction with afobazole (5-ethoxy-2-[2-morpholino)-ethylthio] benzimidasole dihydrochloride) resulted in shrinkage of the ischemic damage area in the heart, stimulation of reparative processes in the myocardium, and prevention of postinfarction remodeling of the left ventricle. Anti-ischemic effect of afobazole in experimental myocardial infarction is presumably due to its interactions with σ(1) receptors.

摘要

用阿福唑（5-乙氧基-2-[2-吗啉基）-乙硫基]苯并咪唑二盐酸盐）对实验性心肌梗死大鼠进行为期七天的治疗，导致心脏缺血损伤区域缩小，刺激心肌的修复过程，并预防左心室梗死后重塑。阿福唑在实验性心肌梗死中的抗缺血作用可能归因于其与σ(1)受体的相互作用。