Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA.
Department of Epidemiology, Biostatistics, and Informatics, University of Pennsylvania, Philadelphia, PA.
Am J Transplant. 2017 Dec;17(12):3183-3192. doi: 10.1111/ajt.14391. Epub 2017 Jul 20.
The shortage of deceased-donor organs is compounded by donation metrics that fail to account for the total pool of possible donors, leading to ambiguous donor statistics. We sought to assess potential metrics of organ procurement organizations (OPOs) utilizing data from the Nationwide Inpatient Sample (NIS) from 2009-2012 and State Inpatient Databases (SIDs) from 2008-2014. A possible donor was defined as a ventilated inpatient death ≤75 years of age, without multi-organ system failure, sepsis, or cancer, whose cause of death was consistent with organ donation. These estimates were compared to patient-level data from chart review from two large OPOs. Among 2,907,658 inpatient deaths from 2009-2012, 96,028 (3.3%) were a "possible deceased-organ donor." The two proposed metrics of OPO performance were: (1) donation percentage (percentage of possible deceased-donors who become actual donors; range: 20.0-57.0%); and (2) organs transplanted per possible donor (range: 0.52-1.74). These metrics allow for comparisons of OPO performance and geographic-level donation rates, and identify areas in greatest need of interventions to improve donation rates. We demonstrate that administrative data can be used to identify possible deceased donors in the US and could be a data source for CMS to implement new OPO performance metrics in a standardized fashion.
器官捐献者的短缺与未能考虑到可能的捐献者总数的捐献指标有关,导致捐献者统计数据不明确。我们试图利用 2009 年至 2012 年的全国住院患者样本(NIS)和 2008 年至 2014 年的州住院患者数据库(SID)的数据,评估器官获取组织(OPO)的潜在指标。潜在捐献者定义为年龄≤75 岁、无多器官系统衰竭、败血症或癌症、呼吸机支持的住院死亡患者,且其死亡原因符合器官捐献。这些估计值与来自两个大型 OPO 的图表审查患者数据进行了比较。在 2009 年至 2012 年期间,2907658 名住院死亡患者中,有 96028 人(3.3%)是“潜在器官捐献者”。OPO 绩效的两个拟议指标为:(1)捐献率(实际捐献者占可能捐献者的百分比;范围:20.0-57.0%);(2)每例潜在捐献者移植的器官数量(范围:0.52-1.74)。这些指标可以比较 OPO 的绩效和地理水平的捐献率,并确定需要采取干预措施以提高捐献率的重点领域。我们证明,管理数据可用于识别美国的潜在器官捐献者,并且可以成为 CMS 以标准化方式实施新的 OPO 绩效指标的数据源。