使用双肿瘤标志物介导的DNA封端多功能介孔二氧化硅纳米颗粒监测“按需”药物释放。

Monitoring of "on-demand" drug release using dual tumor marker mediated DNA-capped versatile mesoporous silica nanoparticles.

作者信息

Wang Song, Liu Fei, Li Xiang-Ling

机构信息

Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, P. R. China.

出版信息

Chem Commun (Camb). 2017 Aug 1;53(62):8755-8758. doi: 10.1039/c7cc02752d.

DOI:10.1039/c7cc02752d

PMID:28726871

Abstract

A versatile drug delivery system with dual specific capacity of controllable release and monitoring of the intracellular release process, which extremely maximize therapeutic efficacy on diseased cells while minimizing drug toxicity to healthy cells, was reported for the first time.

摘要

首次报道了一种具有可控释放和细胞内释放过程监测双重特定能力的多功能药物递送系统，该系统极大地提高了对病变细胞的治疗效果，同时将药物对健康细胞的毒性降至最低。