Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan. China.
Department of Pharmacy, Qilu Hospital of Shandong University, P.O. Box: 250012, Jinan. China.
Curr Pharm Des. 2017;23(23):3367-3382. doi: 10.2174/1381612822666161025153619.
In recent years, nanocarriers have played increasingly significant roles in cancer therapy. Among various nanoplatforms, mesoporous silica nanoparticles (MSNs) have been given serious attention due to their good colloidal stablity, tunable pore sizes, extensive drug loading capacity and easily modified surface. In this review, functionalized MSNs are introduced as an efficient nanocarrier for cancer treatment. First, MSN preparation strategies are generally introduced. Next, passive and active tumor targeting methods for the functionalization of MSNs are reviewed. Then, several types of stimuli-responsive strategies for on-demand drug release, a wide variety of designs integrating with magnetic resonance imaging agents, optical imaging agents, and positron emission tomography imaging agents, etc. for theranostic purpose are summarized. A discussion relating to the future perspectives of MSNs for clinical translocation is also included in this review.
近年来，纳米载体在癌症治疗中发挥了越来越重要的作用。在各种纳米平台中，介孔硅纳米粒子（MSNs）由于其良好的胶体稳定性、可调的孔径、广泛的药物负载能力和易于修饰的表面而受到了广泛关注。在本综述中，功能化 MSNs 被介绍为一种用于癌症治疗的有效纳米载体。首先，一般介绍 MSN 的制备策略。接下来，综述了 MSNs 功能化的被动和主动肿瘤靶向方法。然后，总结了几种用于按需药物释放的刺激响应策略，以及将多种设计与磁共振成像剂、光学成像剂和正电子发射断层成像剂等相结合的用于治疗目的的方法。本综述还讨论了 MSNs 用于临床转化的未来前景。
