White Alexandra J, Sandler Dale P
Epidemiology Branch, National Institute of Environmental Health Sciences, NIH , Research Triangle Park, North Carolina, USA.
Environ Health Perspect. 2017 Jul 18;125(7):077011. doi: 10.1289/EHP827.
Indoor burning of fuel for heating or cooking releases carcinogens. Little is known about the impact of indoor air pollution from wood-burning stoves or fireplaces on breast cancer risk.
In a large prospective cohort study, we evaluated the risk of breast cancer in relation to indoor heating and cooking practices.
Sister Study participants (=50,884) were recruited from 2003–2009. Breast cancer–free women in the United States or Puerto Rico, 35–74 y old, with a sister with breast cancer were eligible. Participants completed questionnaires on indoor heating and cooking practices for both their enrollment and their longest adult residence. Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the association between indoor heating/cooking and breast cancer.
A total of 2,416 breast cancer cases were diagnosed during follow-up (mean=6.4 y). Having an indoor wood-burning stove/fireplace in the longest adult residence was associated with a higher breast cancer risk [HR=1.11 (95% CI: 1.01, 1.22)]; the risk increased with average frequency of use [≥once/week, HR=1.17 (95% CI: 1.02, 1.34)] (p for trend=0.01). An elevated HR was seen for women burning wood [HR=1.09 (95% CI: 0.98, 1.21)] or natural gas/propane [HR=1.15 (95% CI: 1.00, 1.32)]. No association was observed for burning artificial fire-logs [HR=0.98 (95% CI: 0.85, 1.12)] except among women from western states [HR=1.36 (95% CI: 1.02, 1.81)].
In this prospective study, using an indoor wood-burning stove/fireplace in the longest adult residence at least once a week and burning either wood or natural gas/propane was associated with a modestly higher risk of breast cancer. https://doi.org/10.1289/EHP827.
室内燃烧燃料用于取暖或烹饪会释放致癌物质。关于燃木炉灶或壁炉造成的室内空气污染对乳腺癌风险的影响，人们了解甚少。
在一项大型前瞻性队列研究中，我们评估了与室内取暖和烹饪方式相关的乳腺癌风险。
“姐妹研究”的参与者（n = 50,884）于2003年至2009年招募。美国或波多黎各年龄在35至74岁、有患乳腺癌姐妹的无乳腺癌女性符合条件。参与者就其登记时以及成年后居住时间最长的住所的室内取暖和烹饪方式填写了问卷。采用Cox回归来估计室内取暖/烹饪与乳腺癌之间关联的调整风险比（HR）和95%置信区间（95%CI）。
随访期间共诊断出2416例乳腺癌病例（平均随访6.4年）。在成年后居住时间最长的住所使用室内燃木炉灶/壁炉与较高的乳腺癌风险相关[HR = 1.11（95%CI：1.01, 1.22）]；风险随平均使用频率增加而升高[≥每周一次，HR = 1.17（95%CI：1.02, 1.34）]（趋势p值 = 0.01）。燃烧木材[HR = 1.09（95%CI：0.98, 1.21）]或天然气/丙烷[HR = 1.15（95%CI：1.00, 1.32）]的女性的HR升高。除了西部各州的女性外，燃烧人造木柴未观察到关联[HR = 0.98（95%CI：0.85, 1.12）] [西部各州女性的HR = 用于取暖或烹饪会释放致癌物质。关于燃木炉灶或壁炉造成的室内空气污染对乳腺癌风险的影响，人们了解甚少。
在一项大型前瞻性队列研究中,我们评估了与室内取暖和烹饪方式相关的乳腺癌风险。
“姐妹研究”的参与者(n = 50,884)于2003年至2009年招募。美国或波多黎各年龄在35至74岁、有患乳腺癌姐妹的无乳腺癌女性符合条件。参与者就其登记时以及成年后居住时间最长的住所的室内取暖和烹饪方式填写了问卷。采用Cox回归来估计室内取暖/烹饪与乳腺癌之间关联的调整风险比(HR)和95%置信区间(95%CI)。
随访期间共诊断出2416例乳腺癌病例(平均随访6.4年)。在成年后居住时间最长的住所使用室内燃木炉灶/壁炉与较高的乳腺癌风险相关[HR = 1.11(95%CI: 1.01, 1.22)]；风险随平均使用频率增加而升高[≥每周一次，HR = 1.17(95%CI: 1.02, 1.34)] (趋势p值 = 0.01)。燃烧木材[HR = 1.09(95%CI: 0.98, 1.21)]或天然气/丙烷[HR = 1.15(95%CI: 1.00, 1.32)]的女性的HR升高。除了西部各州的女性外，燃烧人造木柴未观察到关联[HR = 0.98(95%CI: 0.85, 1.12)] [西部各州女性的HR = 1.36(95%CI: 1.02, 1.81)]。
在这项前瞻性研究中，在成年后居住时间最长的住所每周至少使用一次室内燃木炉灶/壁炉以及燃烧木材或天然气/丙烷与略高的乳腺癌风险相关。https://doi.org/10.1289/EHP827。 1.36（95%CI：1.02, 1.81）]。
在这项前瞻性研究中，在成年后居住时间最长的住所每周至少使用一次室内燃木炉灶/壁炉以及燃烧木材或天然气/丙烷与略高的乳腺癌风险相关。https://doi.org/10.1289/EHP827。
