Department of Medicine, Section of Geriatrics, University of Verona, Italy.
Eur J Prev Cardiol. 2017 Sep;24(14):1532-1540. doi: 10.1177/2047487317721655. Epub 2017 Jul 21.
Background Only a few studies have investigated the relationship between neck circumference and cardiometabolic risk. The aim of this study was to assess the relationships between neck circumference, waist circumference, metabolic variables and arterial stiffness in a group of overweight and obese subjects evaluating a possible independent role of neck circumference in determining arterial stiffness. Methods and results We studied 95 subjects (53 women) with an age range of 20-77 years and body mass index range from 25.69 to 47.04 kg/m. In each subject we evaluated body mass index, waist, hip and neck circumference, systolic and diastolic blood pressure, insulin, fasting glucose, cholesterol, low-density lipoprotein and high-density lipoprotein cholesterol and triglycerides. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (PWVcf) and carotid-radial pulse wave velocity (PWVcr). Both PWVcf and PWVcr were higher in subjects with high values of neck circumference compared with subjects with normal values of neck circumference. Subjects with high values of neck circumference and abdominal obesity presented higher values of mean arterial pressure, PWVcr and homeostasis model assessment (HOMA) index and lower values of high-density lipoprotein than subjects with only abdominal obesity. Two models of stepwise multiple regression were performed in order to evaluate the combined effect of independent variables on arterial stiffness. In the first model PWVcf was considered a dependent variable, and age, gender, systolic blood pressure, triglycerides, high-density lipoprotein cholesterol, waist circumference, neck circumference, HOMA index and the use of anti-hypertensive medications were considered independent variables. Age, systolic blood pressure, triglycerides and waist circumference were significant predictors of PWVcf, explaining 65% of its variance. In the second model, in which PWVcr was considered a dependent variable, neck circumference and gender were significant predictors of PWVcr, explaining 24% of its variance. Conclusions These findings emphasise the need to measure not only waist but even neck circumference to better stratify and identify individuals at increased cardiometabolic risk, as upper-body subcutaneous fat is a novel, easily measured fat depot.
仅有少数研究调查了颈围与心血管代谢风险之间的关系。本研究旨在评估超重和肥胖人群中颈围、腰围、代谢变量和动脉僵硬度之间的关系，并评估颈围在确定动脉僵硬度方面的可能独立作用。
我们研究了 95 名年龄在 20-77 岁、体重指数范围在 25.69-47.04kg/m2之间的受试者。在每位受试者中，我们评估了体重指数、腰围、臀围和颈围、收缩压和舒张压、胰岛素、空腹血糖、胆固醇、低密度脂蛋白和高密度脂蛋白胆固醇以及甘油三酯。通过颈-股脉搏波速度（PWVcf）和颈-桡脉搏波速度（PWVcr）评估动脉僵硬度。与颈围正常的受试者相比，颈围值较高的受试者的 PWVcf 和 PWVcr 均较高。颈围值较高且存在腹型肥胖的受试者的平均动脉压、PWVcr 和稳态模型评估（HOMA）指数较高，高密度脂蛋白胆固醇水平较低，而仅存在腹型肥胖的受试者则相反。进行了两项逐步多元回归模型，以评估独立变量对动脉僵硬度的综合影响。在第一个模型中，将 PWVcf 视为因变量，将年龄、性别、收缩压、甘油三酯、高密度脂蛋白胆固醇、腰围、颈围、HOMA 指数和使用抗高血压药物视为独立变量。年龄、收缩压、甘油三酯和腰围是 PWVcf 的显著预测因子，解释了其 65%的变异性。在第二个模型中，将 PWVcr 视为因变量，颈围和性别是 PWVcr 的显著预测因子，解释了其 24%的变异性。
这些发现强调了不仅要测量腰围，甚至要测量颈围，以更好地分层和识别心血管代谢风险增加的个体，因为上半身皮下脂肪是一种新的、易于测量的脂肪储存库。
