Sobhani Sahar, Vakili Saba, Javid Jam Dina, Aryan Reihaneh, Khadem-Rezaiyan Majid, Eslami Saeid, Alinezhad-Namaghi Maryam
Department of Nursing and Midwifery Faculty of Nursing Gonabad University of Medical Sciences Gonabad Iran.
Medical Genetics Research Center Mashhad University of Medical Sciences Mashhad Iran.
Obes Sci Pract. 2022 Jan 4;8(4):494-499. doi: 10.1002/osp4.582. eCollection 2022 Aug.
Obesity and arteriosclerosis are both independently associated with cardiovascular disease risk. Obesity also may increase arterial stiffness.
This study aimed to investigate the association between anthropometric indices and non-invasive arterial stiffness parameters, using data from a large population-based cohort of seemingly healthy women and men.
A total of 5023 eligible participants were included in the study. The pulse wave velocity (PWV), central blood pressures, and bio-impedance measures were obtained at the time of enrollment. Multiple regression analysis was performed to assess the relationship between anthropometric indices with arterial stiffness parameters.
The mean age of participants was 45.3 ± 8.8 years, 2368 (47.1%) were males and 2655 (52.8%) were females. The prevalence of participant with underweight, normal weight, overweight, and obesity were 0.73%, 33.2%, 48.7%, and 17.2% respectively. Systolic and diastolic blood pressure, fatty liver, and hypertension were significantly higher in overweight/obesity participants. The overweight/obesity participants had significantly higher PWV than the normal-weight group (471.5 ± 42.6/496.7 ± 47.5 cm/s vs. 448.1 ± 41.4 cm/s, < 0.001).
The prevalence of diabetes, hypertension, fatty liver disease, chronic lung disease, and also kidney stones were significantly higher in overweight and individuals with obesity. Body mass index, body fat mass, waist-hip ratio abdominal circumference, neck circumference, visceral fat area, total body water, 50-kHz whole body phase angle are positively correlated with PWV. Augmentation index had no significant correlation with body mass index, arm, hip, and abdominal circumferences.
肥胖和动脉硬化均与心血管疾病风险独立相关。肥胖还可能增加动脉僵硬度。
本研究旨在利用来自一个基于大样本人群的看似健康的男性和女性队列的数据，调查人体测量指标与非侵入性动脉僵硬度参数之间的关联。
共有5023名符合条件的参与者纳入本研究。在入组时获取脉搏波速度（PWV）、中心血压和生物阻抗测量值。进行多元回归分析以评估人体测量指标与动脉僵硬度参数之间的关系。
参与者的平均年龄为45.3±8.8岁，男性2368名（47.1%），女性2655名（52.8%）。体重过轻、正常体重、超重和肥胖参与者的患病率分别为0.73%、33.2%、48.7%和17.2%。超重/肥胖参与者的收缩压和舒张压、脂肪肝和高血压显著更高。超重/肥胖参与者的PWV显著高于正常体重组（471.5±42.6/496.7±47.5厘米/秒对448.1±41.4厘米/秒，<0.001）。
超重和肥胖个体中糖尿病、高血压、脂肪肝病、慢性肺病以及肾结石的患病率显著更高。体重指数、体脂肪量、腰臀比、腹围、颈围、内脏脂肪面积、全身水含量、50千赫兹全身相位角与PWV呈正相关。增强指数与体重指数、臂围、臀围和腹围无显著相关性。
