Amlung Michael, MacKillop James, Monti Peter M, Miranda Robert
Peter Boris Centre for Addictions Research, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton,Ontario, Canada.
Homewood Research Institute, Homewood Health Centre, Guelph, Ontario, Canada.
J Stud Alcohol Drugs. 2017 May;78(4):623-628. doi: 10.15288/jsad.2017.78.623.
Cigarette smokers are more likely to consume alcohol at higher levels and experience poorer response to treatment for alcohol problems than are nonsmokers. One previous study in university students suggests that a potential reason for the high overlap between alcohol and tobacco use is that concurrent smoking is associated with overvaluation of alcohol, as reflected in elevated behavioral economic demand. The present study sought to extend these initial findings in a community sample with heavier levels of alcohol and tobacco use.
Participants were 111 non-treatment-seeking heavy drinkers(defined as 18+/14+ drinks per week for men/women) from a larger study on alcohol pharmacotherapy mechanisms. Forty-nine participants (44%) reported regular smoking (≥5 cigarettes/day). Participants completed a hypothetical alcohol purchase task assessing alcohol consumption at escalating levels of price. Covariates included demographics, drinking quantity, alcohol use disorder severity, depression, and delay discounting.
In covariate-adjusted models, smokers reported significantly higher maximum alcohol expenditures (O) and breakpoint price (first price suppressing consumption to zero) compared with nonsmokers. Elevated alcohol demand correlated with drinking quantity and severity in the entire sample, but not with smoking frequency or nicotine dependence among smokers only.
This study offers further evidence of increased reinforcing value of alcohol among smokers in a sample of heavy drinkers from the community. Clinical implications and potential mechanisms underlying this relationship are discussed.
与不吸烟者相比,吸烟者更有可能大量饮酒,并且对酒精问题的治疗反应较差。之前一项针对大学生的研究表明,酒精和烟草使用高度重叠的一个潜在原因是,同时吸烟与对酒精的过度重视有关,这在行为经济学需求升高方面有所体现。本研究旨在将这些初步发现扩展到一个酒精和烟草使用水平更高的社区样本中。
参与者是来自一项关于酒精药物治疗机制的大型研究的111名未寻求治疗的重度饮酒者(定义为男性每周饮用18杯及以上/女性每周饮用14杯及以上)。49名参与者(44%)报告有规律吸烟(每天≥5支香烟)。参与者完成了一项假设性酒精购买任务,该任务评估了在价格不断上涨的情况下的酒精消费情况。协变量包括人口统计学特征、饮酒量、酒精使用障碍严重程度、抑郁和延迟折扣。
在经协变量调整的模型中,与不吸烟者相比,吸烟者报告的最大酒精支出(O)和断点价格(将消费抑制为零的首个价格)显著更高。在整个样本中,酒精需求升高与饮酒量和严重程度相关,但仅在吸烟者中与吸烟频率或尼古丁依赖无关。
本研究为社区重度饮酒者样本中吸烟者对酒精的强化价值增加提供了进一步证据。讨论了这种关系的临床意义和潜在机制。