Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL, 32610, United States; Center for Pain Research and Behavioral Health, University of Florida, PO Box 100165, Gainesville, FL, 32610, United States.
Department of Psychology, University of Florida, PO Box 112250, Gainesville, FL, 32611, United States.
Drug Alcohol Depend. 2021 Feb 1;219:108475. doi: 10.1016/j.drugalcdep.2020.108475. Epub 2020 Dec 20.
Pain may serve as an antecedent for alcohol use, increasing risk for hazardous drinking and associated consequences. Delayed onset muscle soreness (DOMS) induction produces clinically relevant but time-limited musculoskeletal pain. This study was conducted to determine whether DOMS induction on the dominant elbow flexors influenced alcohol demand using the Alcohol Purchase Task (APT). We hypothesized DOMS would increase alcohol demand relative to a sham control. Based on existing studies of pain self-medication, we expected DOMS-related increases in alcohol demand would be greatest in men.
Participants (N = 53; 57 % women) were randomly assigned to a DOMS (eccentric exercise) or sham condition (concentric exercise). Participants completed the APT pre-exercise and 48 -hs post-exercise. Repeated measures GLM was used to characterize group by sex by time interactions on APT indices, including intensity, breakpoint, essential value (EV), O, and P.
The DOMS procedure significantly increased pain ratings at the elbow flexors. Men had significantly higher demand intensity than women across groups and time points. Significant interactive effects were detected for breakpoint and EV. From pre- to post-test, breakpoint significantly increased in men in the DOMS group. However, breakpoint and EV significantly decreased in women in the DOMS group.
Increased alcohol demand in men in the DOMS group was consistent with epidemiological data suggesting men are at higher risk for self-medicating pain with alcohol than women. However, decreased demand in women was unexpected. Taken together, results indicate DOMS induction may be a useful means to characterize pain as an antecedent for alcohol use.
疼痛可能是饮酒的前兆，增加了危险饮酒和相关后果的风险。延迟发作的肌肉酸痛（DOMS）会引起临床上相关但时间有限的肌肉骨骼疼痛。本研究旨在确定在优势侧肘屈肌上诱导 DOMS 是否会通过酒精购买任务（APT）影响酒精需求。我们假设 DOMS 会增加相对于假对照的酒精需求。基于疼痛自我治疗的现有研究，我们预计与 DOMS 相关的酒精需求增加在男性中最大。
参与者（N = 53；57%女性）被随机分配到 DOMS（离心运动）或假对照（向心运动）条件。参与者在运动前和 48 小时后完成 APT。使用重复测量 GLM 来描述 APT 指数（包括强度、断点、基本值（EV）、O 和 P）上的组间性别交互作用。
DOMS 程序显著增加了肘屈肌的疼痛评分。男性在各组和各时间点的需求强度均显著高于女性。断点和 EV 存在显著的交互效应。从预测试到测试后，DOMS 组的男性断点显著增加。然而，DOMS 组的女性断点和 EV 显著下降。
DOMS 组男性的酒精需求增加与流行病学数据一致，表明男性比女性更有可能用酒精自我治疗疼痛。然而，女性需求的减少是出乎意料的。总之，结果表明 DOMS 诱导可能是一种有用的方法来描述疼痛作为饮酒的前兆。
