Palkovits M, Láng T, Patthy A, Elekes I
Brain Res. 1986 May 14;373(1-2):252-7. doi: 10.1016/0006-8993(86)90339-2.
Concentrations of glutamate and aspartate have been measured in 45 microdissected brain areas and nuclei in rat. Both amino acids are ubiquitously present and distributed unevenly in the central nervous system. Very high glutamate levels were found in the cerebellum and the insular cortex, high levels in neocortical and limbic cortical areas, and in the nuclei of the medial hypothalamus. Aspartate is distributed rather uniformly with the highest concentration in the hypothalamic arcuate nucleus and the lowest in the midbrain central gray matter and the cerebellum. Acute formalin (pain) stress elevated glutamate and aspartate levels in the cortical areas and substantia nigra significantly, but had minor or no effects on other brain nuclei. Increased locomotor and behavioral activities due to a high dose of amphetamine resulted in a 2-5-fold increase of glutamate and aspartate concentrations, particularly in the biogenic amine-containing brain nuclei.
已对大鼠45个显微切割的脑区和神经核中的谷氨酸和天冬氨酸浓度进行了测量。这两种氨基酸在中枢神经系统中普遍存在且分布不均。在小脑和岛叶皮质中发现谷氨酸水平非常高，在新皮质和边缘皮质区域以及下丘脑内侧核中水平较高。天冬氨酸分布较为均匀，在下丘脑弓状核中浓度最高，在中脑中央灰质和小脑中最低。急性福尔马林（疼痛）应激显著提高了皮质区域和黑质中的谷氨酸和天冬氨酸水平，但对其他脑核影响较小或无影响。高剂量苯丙胺导致的运动和行为活动增加，使谷氨酸和天冬氨酸浓度增加了2至5倍，特别是在含生物胺的脑核中。
