Daugherty Alan, Tall Alan R, Daemen Mat J A P, Falk Erling, Fisher Edward A, García-Cardeña Guillermo, Lusis Aldons J, Owens A Phillip, Rosenfeld Michael E, Virmani Renu
Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):e131-e157. doi: 10.1161/ATV.0000000000000062. Epub 2017 Jul 20.
Animal studies are a foundation for defining mechanisms of atherosclerosis and potential targets of drugs to prevent lesion development or reverse the disease. In the current literature, it is common to see contradictions of outcomes in animal studies from different research groups, leading to the paucity of extrapolations of experimental findings into understanding the human disease. The purpose of this statement is to provide guidelines for development and execution of experimental design and interpretation in animal studies. Recommendations include the following: (1) animal model selection, with commentary on the fidelity of mimicking facets of the human disease; (2) experimental design and its impact on the interpretation of data; and (3) standard methods to enhance accuracy of measurements and characterization of atherosclerotic lesions.
动物研究是确定动脉粥样硬化机制以及预防病变发展或逆转该疾病的药物潜在靶点的基础。在当前文献中，不同研究小组的动物研究结果相互矛盾的情况很常见，这导致将实验结果外推以理解人类疾病的情况很少。本声明的目的是为动物研究的实验设计和解释的制定与实施提供指导方针。建议如下：（1）动物模型的选择，并对模拟人类疾病各方面的逼真度进行评论；（2）实验设计及其对数据解释的影响；（3）提高动脉粥样硬化病变测量和表征准确性的标准方法。
