Segawa K, Nagai T, Tanaka N, Nishiyama K
Clin Ther. 1986;8(3):263-8.
The effects on corneal tissue of three marketed beta-blocker eye drops, carteolol 1% and 2%, befunolol 0.5% and 1%, and timolol 0.25% and 0.5%, were studied by instilling these drops into the eyes of rabbits twice daily for two consecutive months. The corneal sections were examined under a scanning electron microscope and a transmission electron microscope. Carteolol eye drops caused no pathological change in the corneal epithelium, whereas befunolol and timolol eye drops caused pronounced desquamation of the corneal epithelium and pronounced disappearance of microvilli. None of the three beta-blocker eye drops caused pathological changes in the parenchyma or endothelium of the cornea.
通过连续两个月每天两次将三种市售β受体阻滞剂滴眼液（1%和2%的卡替洛尔、0.5%和1%的倍他洛尔、0.25%和0.5%的噻吗洛尔）滴入兔眼，研究了它们对角膜组织的影响。在扫描电子显微镜和透射电子显微镜下检查角膜切片。卡替洛尔滴眼液未引起角膜上皮的病理变化，而倍他洛尔和噻吗洛尔滴眼液导致角膜上皮明显剥脱和微绒毛明显消失。三种β受体阻滞剂滴眼液均未引起角膜实质或内皮的病理变化。
