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固定剂量利尿剂和β受体阻滞剂的降压治疗：拉贝洛尔加氯噻酮与阿替洛尔加氯噻酮联合用药的比较。

Antihypertensive therapy with diuretics and beta-blockers at fixed dosage: comparison between the combinations labetalol plus chlorthalidone and atenolol plus chlorthalidone.

作者信息

Roja M, Cumetti C, Vergani A, Montanari C, De Cristofaro A

出版信息

Drugs Exp Clin Res. 1985;11(12):851-60.

PMID:2873012
Abstract

The aim of this study was a comparison between the hypotensive effects of two fixed combinations (atenolol + chlorthalidone and labetalol + chlorthalidone) in patients suffering from untreated mild to moderate hypertension. Both combinations were effective in reduction of BP values. Heart rate showed no statistically significant modification. The combination of labetalol plus chlorthalidone seems to find its best application in the treatment of mild hypertension.

摘要

本研究的目的是比较两种固定复方制剂（阿替洛尔+氢氯噻嗪和拉贝洛尔+氢氯噻嗪）对未经治疗的轻至中度高血压患者的降压效果。两种复方制剂均能有效降低血压值。心率无统计学意义上的改变。拉贝洛尔加氢氯噻嗪的复方制剂似乎最适用于轻度高血压的治疗。

相似文献

1
Antihypertensive therapy with diuretics and beta-blockers at fixed dosage: comparison between the combinations labetalol plus chlorthalidone and atenolol plus chlorthalidone.固定剂量利尿剂和β受体阻滞剂的降压治疗：拉贝洛尔加氯噻酮与阿替洛尔加氯噻酮联合用药的比较。
Drugs Exp Clin Res. 1985;11(12):851-60.
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Changes in blood pressure and thermographic values resulting from use of a beta-blocker plus diuretic and of an alpha-beta-blocker plus diuretic.
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[Cardiovascular response to isometric exercise test during beta blocker and diuretic treatment in essential arterial hypertension].[原发性高血压患者在β受体阻滞剂和利尿剂治疗期间等长运动试验的心血管反应]
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[Comparison of labetalol as a single treatment and labetalol combined with chlorthalidone in the treatment of severe arterial hypertension].拉贝洛尔单药治疗与拉贝洛尔联合氯噻酮治疗重度动脉高血压的比较
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Low-dose atenolol-chlorthalidone combination for treatment of mild hypertension.小剂量阿替洛尔-氢氯噻嗪联合用药治疗轻度高血压
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引用本文的文献

1
Fixed-dose combination antihypertensive drugs. Do they have a role in rational therapy?固定剂量复方抗高血压药物。它们在合理治疗中起作用吗？
Drugs. 1994 Jul;48(1):16-24. doi: 10.2165/00003495-199448010-00003.
2
Labetalol. A reappraisal of its pharmacology, pharmacokinetics and therapeutic use in hypertension and ischaemic heart disease.拉贝洛尔：对其药理学、药代动力学以及在高血压和缺血性心脏病治疗中的应用的重新评估。
Drugs. 1989 May;37(5):583-627. doi: 10.2165/00003495-198937050-00002.