Shang Wenjun, Feng Yonghua, Li Jinfeng, Wang Xinzhou, Xie Hongchang, Feng Guiwen
Department of Kidney Transplantation, First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Open Med (Wars). 2017 May 4;12:62-69. doi: 10.1515/med-2017-0012. eCollection 2017.
Liver injury is one of the most common complications in patients after kidney transplantation. Bicyclol tablets possess obvious anti-inflammatory and liver-protective functions. This study aimed to explore the clinical effect of preventive application of Bicyclol on drug induced liver injuries at an early stage after kidney transplantation. A total of 1600 patients who accepted kidney transplantations at our hospital from January 2009 to May 2015 were enrolled in this study, and divided into the prevention group (Bicyclol) and the control group (no hepatic protectors) based on whether or not hepatic protectors were regularly administered after the operation. The occurrence of liver injuries at an early stage after the operation and their influencing factors were analyzed. Total of 745 cases were included in the final analysis of which 82 developed liver injuries post-operation, with 22 in the prevention group (4.82%) as compared to 60 in the control group (20.76%) (P= 0.001). As compared to the control group, OR (95% CI) of the prevention group was 0.197 (0.116, 0.334) after revising HBsAg status, age and maintenance immunosuppression. Prophylactic application of Bicyclol as liver-protective treatment was a protective factor against drug induced liver injuries at an early stage after kidney transplantation.
肝损伤是肾移植患者最常见的并发症之一。双环醇片具有明显的抗炎和保肝作用。本研究旨在探讨预防性应用双环醇对肾移植术后早期药物性肝损伤的临床疗效。选取2009年1月至2015年5月在我院接受肾移植的1600例患者，根据术后是否定期使用肝保护剂分为预防组（双环醇）和对照组（未使用肝保护剂）。分析术后早期肝损伤的发生情况及其影响因素。最终纳入分析745例，其中82例术后发生肝损伤，预防组22例（4.82%），对照组60例（20.76%）（P = 0.001）。校正HBsAg状态、年龄和维持性免疫抑制后，预防组与对照组相比，OR（95%CI）为0.197（0.116，0.334）。预防性应用双环醇作为肝保护治疗是肾移植术后早期药物性肝损伤的保护因素。
