Zhang Hui, Wang Jing, Yu Dan, Liu Yan, Xue Kai, Zhao Xue
Department of Otolaryngology Head and Neck Surgery, The Second Hospital of Jilin University, Changchun130041, China.
Open Med (Wars). 2017 Jun 3;12:171-176. doi: 10.1515/med-2017-0025. eCollection 2017.
Southern China experiences larger extent of total cancer pathologies, of which nasopharyngeal carcinoma has the highest incidence under otorhinolaryngeal malignant carcinomas. Risk factor of nasopharyngeal carcinoma varies from hereditary causes to virus infection, among which Epstein-Barr virus (EBV) infection is the mostly investigated. The study into mechanism of EBV in occurrence, development and prognosis of nasopharyngeal carcinoma has been studied for several decades. The pathophysiology in making of EBV into a cancerogen includes proteins as latent membrane protein 1 (LMPs) and nucleic acids as micro-RNAs. In this paper, we reviewed till date studies focusing on relationship between EBV and nasopharyngeal carcinoma.
中国南方的癌症总病理范围更大，其中鼻咽癌在耳鼻喉恶性肿瘤中发病率最高。鼻咽癌的危险因素从遗传因素到病毒感染各不相同，其中爱泼斯坦-巴尔病毒（EBV）感染是研究最多的。关于EBV在鼻咽癌发生、发展和预后中的机制研究已经进行了几十年。EBV成为致癌物的病理生理学包括作为潜伏膜蛋白1（LMPs）的蛋白质和作为微小RNA的核酸。在本文中，我们综述了迄今为止关于EBV与鼻咽癌关系的研究。
