Das D K, Pathan S K, Al-Waheeb S K M, Ali A E, Joneja M, Al-Kanderi M G, John B, Mallik M K
Department of Pathology, Faculty of Medicine, Kuwait University, Al-Jabriya, Kuwait.
Cytology Unit, Mubarak Al-Kabeer Hospital, Al-Jabriya, Kuwait.
Cytopathology. 2017 Oct;28(5):364-370. doi: 10.1111/cyt.12433. Epub 2017 Jul 21.
Compared to other chest wall malignancies, lymphoma is a common disease. However, published literature on a series of lymphoma cases involving the chest wall is scarce. The aim of the present study, was to describe experience with chest wall swellings diagnosed as lymphoid neoplasms on fine needle aspiration (FNA) cytology.
Eleven chest wall swellings were diagnosed as lymphoid neoplasms on FNA over a period of 15 years (January 2000-December 2014). The age of patients ranged from 19 to 73 years (median, 46). The male-to -emale ratio was 7:4. Ten cases had an anterior or lateral chest wall mass, and one swelling was in the scapular region. Six cases had concurrent lymphadenopathy, and one had bone involvement. The FNA smears were reviewed and classified under WHO Classification of Hematopoietic Neoplasms. The histopathological diagnoses were available in eight cases.
The preliminary cytodiagnoses in 11 cases of chest wall lymphoid neoplasms were anaplastic large cell lymphoma (ALCL) in two cases, and ALCL/malignant melanoma, ALCL/T-cell-rich-B-cell lymphoma (TCRBCL)/Hodgkin's lymphoma (HL), plasmacytoma/neuroendocrine carcinoma, Hodgkin's lymphoma, small cell NHL/CLL, NHL, suggestive of NHL, post-transplant peripheral T-cell lymphoma (PTCL), and a malignant plasma cell tumour in one case each. The reviewed cytodiagnoses of lymphoid neoplasms were as follows: ALCL ( five cases), centroblastic lymphoma (two cases), and small cell lymphoma/CLL, post-transplant peripheral T-cell lymphoma, Hodgkin's lymphoma and plasmacytoma (one case each). Histopathological diagnoses available in eight cases confirmed the presence of lymphoid neoplasms.
A variety of lymphoid neoplasms involved the chest wall, and among them, ALCL was a common form.
与其他胸壁恶性肿瘤相比，淋巴瘤是一种常见疾病。然而，关于一系列累及胸壁的淋巴瘤病例的已发表文献却很稀少。本研究的目的是描述经细针穿刺（FNA）细胞学诊断为淋巴样肿瘤的胸壁肿胀的经验。
在15年期间（2000年1月至2014年12月），11例胸壁肿胀经FNA诊断为淋巴样肿瘤。患者年龄在19至73岁之间（中位数为46岁）。男女比例为7:4。10例患者有前胸壁或侧胸壁肿块，1例肿胀位于肩胛区。6例同时伴有淋巴结病，1例有骨受累。对FNA涂片进行了复查，并根据世界卫生组织造血肿瘤分类进行分类。8例有组织病理学诊断结果。
11例胸壁淋巴样肿瘤的初步细胞诊断为：2例间变性大细胞淋巴瘤（ALCL），1例ALCL/恶性黑色素瘤、1例ALCL/T细胞丰富的B细胞淋巴瘤（TCRBCL）/霍奇金淋巴瘤（HL）、1例浆细胞瘤/神经内分泌癌、1例霍奇金淋巴瘤、1例小细胞非霍奇金淋巴瘤/慢性淋巴细胞白血病（CLL）、1例非霍奇金淋巴瘤、1例提示非霍奇金淋巴瘤、1例移植后外周T细胞淋巴瘤（PTCL），1例恶性浆细胞瘤。淋巴样肿瘤的复查细胞诊断如下：ALCL（5例）、中心母细胞淋巴瘤（2例）、小细胞淋巴瘤/CLL、移植后外周T细胞淋巴瘤、霍奇金淋巴瘤和浆细胞瘤（各1例）。8例的组织病理学诊断结果证实存在淋巴样肿瘤。
多种淋巴样肿瘤累及胸壁，其中ALCL是常见类型。
