Kolonić Slobodanka Ostojić, Prasek-Kudrna Katja, Roso Vinko, Radić-Kristo Delfa, Planinc-Peraica Ana, Dzebro Sonja, Kardum-Skelin Ika, Jaksić Branimir
Department of Medicine, University Hospital "Merkur", Zagreb, Croatia.
Coll Antropol. 2010 Mar;34(1):75-9.
The aim of the study was to determine the value and limitations of cytology in diagnosis of Hodgkin's lymphoma (HL) and anaplastic large cell lymphoma (ALCL) as well as differentiation between these two entities. We analysed the FNA cytodiagnoses and histopathological reports, as well as treatment and survival in 89 newly diagnosed consecutive patients with these lymphomas treated in our clinical department. These patients (40 male, 49 female; age range 16-93 years; 44 in clinical stages I-II; 38 with B symptoms) were diagnosed and treated during a period of 64 months (1.1. 2004-1.5.2009). The FNA cytodiagnoses were available in 86 patients and the pathohistological diagnoses were available in 84 patients. Cytology revealed 65 classic HL, 18 ALCL and three patients in which diagnosis was not informative. Among 65 FNA cytodiagnoses of HL, comparison with histopathology was made in 61 cases and the histopathological diagnoses were as follows: 56 (91.8%) HL; three ALCL; one diffuse large B cell lymphoma and one marginal zone B cell lymphoma. In the group of 18 FNA cytodiagnoses of ALCL eight patients (53.3%) had definitive diagnosis of ALCL (either as T-cell or O type), five (33.3%) of HL and in three cases a histopathological diagnosis could not be made. These results confirm the value of FNA in diagnostic procedure in patients with HL and ALCL, especially in HL group of patients. Since we have an almost uniform group of patients according to therapeutic approach, we did univariate analyses and found out that patients with FNA cytodiagnoses of HL, younger than 55 years, with early stage of the disease and without B symptoms had significantly longer overall survival (OS). FNA cytodiagnosis has clinical relevance in differentiation between HL and ALCL.
本研究的目的是确定细胞学在霍奇金淋巴瘤（HL）和间变性大细胞淋巴瘤（ALCL）诊断中的价值和局限性，以及这两种实体之间的鉴别。我们分析了89例在我院临床科室新诊断的连续淋巴瘤患者的细针穿刺抽吸（FNA）细胞诊断和组织病理学报告，以及治疗情况和生存情况。这些患者（40例男性，49例女性；年龄范围16 - 93岁；44例处于临床I - II期；38例有B症状）在64个月（2004年1月1日 - 2009年5月1日）期间被诊断并接受治疗。86例患者有FNA细胞诊断结果，84例患者有病理组织学诊断结果。细胞学检查显示65例经典HL，18例ALCL，3例诊断不明确。在65例HL的FNA细胞诊断中，61例与组织病理学进行了比较，组织病理学诊断结果如下：56例（91.8%）HL；3例ALCL；1例弥漫性大B细胞淋巴瘤和1例边缘区B细胞淋巴瘤。在18例ALCL的FNA细胞诊断组中，8例患者（53.3%）确诊为ALCL（T细胞型或O型），5例（33.3%）为HL，3例无法做出组织病理学诊断。这些结果证实了FNA在HL和ALCL患者诊断过程中的价值，尤其是在HL患者组中。由于我们根据治疗方法有一组几乎同质的患者，我们进行了单因素分析，发现FNA细胞诊断为HL、年龄小于55岁、疾病处于早期且无B症状的患者总生存期（OS）明显更长。FNA细胞诊断在HL和ALCL的鉴别中具有临床意义。
