Albertini G, Davalli R, Moroni P, Oberhauser V
Int J Clin Pharmacol Res. 1986;6(2):113-8.
The effect of tritoqualine on seasonal allergic rhinitis caused by grass pollen was compared to that of dexchlorpheniramine maleate (DCPM) in 21 patients randomly allocated into two parallel groups. There were rapid improvements of all symptoms considered after treatment with either tritoqualine or DCPM. A significant reduction of plasma histamine concentrations was observed during the treatment with tritoqualine whereas no modification occurred with DCPM. Finally, it was shown that tritoqualine did not modify reaction times to visual and auditive stimuli whereas DCPM induced a significant slowing-down of the reaction time to visual stimuli. From this pilot study tritoqualine appears to have the same efficacy for the treatment of seasonal allergic rhinitis as classic anti-H1 antihistamines, but without central nervous system side-effects.
将21名患者随机分为两个平行组，比较了曲托喹啉与马来酸氯苯那敏（DCPM）对草花粉引起的季节性变应性鼻炎的疗效。使用曲托喹啉或DCPM治疗后，所有考虑的症状均迅速改善。在使用曲托喹啉治疗期间观察到血浆组胺浓度显著降低，而DCPM治疗时则无变化。最后，结果表明曲托喹啉不会改变对视觉和听觉刺激的反应时间，而DCPM会导致对视觉刺激的反应时间显著减慢。从这项初步研究来看，曲托喹啉在治疗季节性变应性鼻炎方面似乎与经典的H1抗组胺药具有相同的疗效，但没有中枢神经系统副作用。
