Center for Child Health Research, Faculty of Medicine and Life Sciences, University of Tampere and University Hospital, Tampere, Finland.
Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland.
Acta Paediatr. 2017 Nov;106(11):1837-1841. doi: 10.1111/apa.14000. Epub 2017 Aug 13.
Interleukin-17 (IL-17) appears to promote the host's defence against mycobacterial infections. This study evaluated the association between IL17A gene polymorphism and the risk of Bacillus Calmette-Guérin (BCG) osteitis after newborn vaccination and between IL17A gene polymorphism and IL-17A concentrations in serum.
IL17A rs2275913 gene polymorphisms and serum IL-17A concentrations were studied in 132 adults aged 21-49 years from across Finland, who had BCG osteitis in infancy after a newborn BCG vaccination. The subjects were recruited in 2007-2008, and their whole-blood samples were sent to the National Institute for Health and Welfare, Turku, Finland. Their genotypes and minor allele frequencies were compared with 405 population-based unvaccinated controls aged two to three months from a prospective birth cohort study.
The genotypes and allele frequencies of IL17A rs2275913 differed significantly between the former BCG osteitis patients and controls. The genotype was variant in 75.8% of cases and 64.0% of controls (p = 0.012), and the minor allele frequency was 50.0% in the cases and 41.6% of the controls (p = 0.009). Serum IL-17 concentrations did not differ significantly between the cases with wild or variant genotypes.
IL17A rs2275913 gene polymorphism was associated with a risk of BCG osteitis after vaccination.
白细胞介素-17（IL-17）似乎促进了宿主对分枝杆菌感染的防御。本研究评估了 IL17A 基因多态性与新生儿接种卡介苗（BCG）后发生 BCG 骨炎的风险之间的关系，以及与血清中 IL-17A 浓度之间的关系。
在 2007-2008 年期间，从芬兰各地招募了 132 名年龄在 21-49 岁的成年人，他们在新生儿 BCG 接种后婴儿期患有 BCG 骨炎。将他们的全血样本送往芬兰图尔库国家卫生和福利研究所。将他们的基因型和次要等位基因频率与来自前瞻性出生队列研究的 2 至 3 个月龄未接种疫苗的 405 名对照者进行比较。
IL17A rs2275913 的基因型和等位基因频率在前 BCG 骨炎患者和对照组之间存在显著差异。病例组的基因型为变异型的占 75.8%，对照组为 64.0%（p=0.012），病例组的次要等位基因频率为 50.0%，对照组为 41.6%（p=0.009）。野生型或变异型基因型患者的血清 IL-17 浓度无显著差异。
IL17A rs2275913 基因多态性与接种后 BCG 骨炎的风险相关。
