Department of Oral Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Department of Oral and Maxillofacial Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
J Int Med Res. 2020 Dec;48(12):300060520976833. doi: 10.1177/0300060520976833.
Interleukin (IL)-17 is a multifunctional cytokine with important roles in inflammatory and autoimmune diseases. This case-control study explored the relationships of IL-17A rs2275913 and IL-17F rs763780 single-nucleotide polymorphisms (SNPs) with recurrent aphthous ulcer (RAU) morbidity and severity.
IL-17A rs2275913 and IL-17F rs763780 SNPs were measured in 125 patients with RAU and 116 healthy control participants. The genotype distributions, disease risks, and relationships with RAU severity were analyzed.
RAU risk was associated with rs2275913 after adjustment for age, body mass index, sex, smoking status, and drinking status (AA vs. GG: odds ratio [OR], 2.759; 95% confidence interval [CI], 1.381-5.512; A allele vs. G allele: OR, 1.783; 95% CI, 1.242-2.560). TC and CC genotypes in rs763780, and the corresponding C allele, demonstrated greater prevalence among patients with RAU, compared with the TT genotype (TC vs. TT, OR: 1.895; 95% CI: 1.088-3.301; CC vs. TT, OR: 4.080, 95% CI: 1.079-15.425; C allele vs. T allele, OR: 1.969, 95% CI: 1.257-3.083). Serum IL-17 concentrations were also higher in patients with RAU than in control participants. These concentrations were associated with IL-17 polymorphisms.
IL-17 polymorphisms might be associated with greater risk of RAU pathogenesis.
白细胞介素（IL）-17 是一种多功能细胞因子，在炎症和自身免疫性疾病中具有重要作用。本病例对照研究探讨了白细胞介素-17A rs2275913 和白细胞介素-17F rs763780 单核苷酸多态性（SNP）与复发性阿弗他溃疡（RAU）发病率和严重程度的关系。
在 125 例 RAU 患者和 116 例健康对照参与者中测量了白细胞介素-17A rs2275913 和白细胞介素-17F rs763780 SNP。分析了基因型分布、疾病风险与 RAU 严重程度的关系。
调整年龄、体重指数、性别、吸烟状况和饮酒状况后，RAU 风险与 rs2275913 相关（AA 与 GG：比值比[OR]，2.759；95%置信区间[CI]，1.381-5.512；A 等位基因与 G 等位基因：OR，1.783；95%CI，1.242-2.560）。rs763780 的 TC 和 CC 基因型以及相应的 C 等位基因在 RAU 患者中比 TT 基因型更为常见（TC 与 TT：OR，1.895；95%CI，1.088-3.301；CC 与 TT：OR，4.080，95%CI，1.079-15.425；C 等位基因与 T 等位基因：OR，1.969，95%CI，1.257-3.083）。RAU 患者的血清白细胞介素-17 浓度也高于对照组。这些浓度与白细胞介素-17 多态性相关。
白细胞介素-17 多态性可能与 RAU 发病机制的风险增加有关。
