Leary Jacob B, Kim Grace Y, Bradley Catherine L, Hussain Uzma Z, Sacco Maryanne, Bernad Martha, Collins John, Dsurney John, Chan Leighton
Rehabilitation Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland (Mr Leary, Mss Kim, Bradley, Hussain, and Sacco, and Drs Bernad and Chan); Department of Rehabilitation Science, College of Health and Human Services, George Mason University, Fairfax, Virginia (Dr Collins); and Center for Neuroscience and Regenerative Medicine, National Institutes of Health, Bethesda, Maryland (Drs Dsurney and Chan).
J Head Trauma Rehabil. 2018 Jan/Feb;33(1):E28-E35. doi: 10.1097/HTR.0000000000000329.
Examine the association of cognitive reserve (CR) factors (estimated premorbid intelligence quotient [IQ], years of education, and occupational attainment) and traumatic brain injury (TBI) severity with functional and neuropsychological outcomes 1 to 5 years following TBI.
Patients with mild (N = 58), moderate (N = 25), or severe (N = 17) TBI.
Cognitive reserve factors (estimated premorbid IQ, years of education, and occupational attainment); neuropsychological test battery; Glasgow Outcome Scale-Extended; Short Form-36 Health Survey.
Spearman-Brown correlations, linear regression models, and analyses of covariance were used to analyze the relation between CR factors and outcome measures.
Analyses revealed significant relations between estimated premorbid IQ and neuropsychological outcomes (P < .004): California Verbal Learning Test, Wechsler Adult Intelligence Scale-Fourth Edition working memory, Booklet Category Test, Trail Making Test B, and Grooved Pegboard Test. There was also a significant correlation between estimated premorbid IQ and Wechsler Adult Intelligence Scale-Fourth Edition processing speed. Years of education had significant relations with California Verbal Learning Test and Wechsler Adult Intelligence Scale-Fourth Edition working memory and processing speed scores. There were significant differences between TBI severity groups and performance on the Trail Making Test A, Grooved Pegboard Test, and Finger Tapping Test.
Cognitive reserve factors may be associated with outcomes following TBI. Additional alternatives to TBI severity are needed to help guide rehabilitative planning postinjury.
研究认知储备（CR）因素（预估病前智商[IQ]、受教育年限和职业成就）及创伤性脑损伤（TBI）严重程度与TBI后1至5年的功能和神经心理学结果之间的关联。
轻度（N = 58）、中度（N = 25）或重度（N = 17）TBI患者。
认知储备因素（预估病前智商、受教育年限和职业成就）；神经心理测试组；格拉斯哥扩展预后量表；健康调查简表36。
采用斯皮尔曼 - 布朗相关性分析、线性回归模型和协方差分析来分析CR因素与结果测量指标之间的关系。
分析显示预估病前智商与神经心理学结果之间存在显著关系（P < .004）：加利福尼亚言语学习测试、韦氏成人智力量表第四版工作记忆、分类测试手册、连线测验B和明尼苏达操作速度测验。预估病前智商与韦氏成人智力量表第四版处理速度之间也存在显著相关性。受教育年限与加利福尼亚言语学习测试以及韦氏成人智力量表第四版工作记忆和处理速度得分之间存在显著关系。TBI严重程度组在连线测验A、明尼苏达操作速度测验和手指敲击测验中的表现存在显著差异。
认知储备因素可能与TBI后的结果相关。需要TBI严重程度之外的其他因素来帮助指导伤后康复计划。
