Czul Frank, Coronel Emmanuel, Donet Jean A
Gastroenterology, Presbyterian Healthcare Services. Albuquerque, EE UU.
Division of Gastroenterology, University of Chicago. Chicago, EE UU.
Rev Gastroenterol Peru. 2017 Apr-Jun;37(2):146-155.
Chronic pancreatitis is a progressive fibro-inflammatory disease of the pancreas characterized by irreversible fibrosis of the gland with eventual failure of exocrine and endocrine functions and hallmark features of abdominal pain, malabsorption, malnutrition, diabetes mellitus and pancreatic calcifications. In many patients this disease results from a complex mix of environmental (eg, alcohol, cigarettes, and occupational chemicals), genetic factors and a few patients with hereditary or autoimmune disease. The management includes medical, endoscopic and surgical approaches with the need for interaction between various specialties, calling for a concerted multidisciplinary approach. This review provides the reader with a comprehensive overview of the studies summarizing the epidemiology, etiology, physiopatology, clinical manifestation, diagnosis and treatments of the disease.
慢性胰腺炎是一种胰腺的进行性纤维炎症性疾病，其特征是胰腺出现不可逆纤维化，最终导致外分泌和内分泌功能衰竭，并伴有腹痛、吸收不良、营养不良、糖尿病和胰腺钙化等标志性特征。在许多患者中，这种疾病是由环境因素（如酒精、香烟和职业化学品）、遗传因素以及少数患有遗传性或自身免疫性疾病的患者共同作用的复杂结果。其治疗包括药物、内镜和手术方法，需要各专科之间相互协作，因此需要采取协调一致的多学科方法。本综述为读者提供了对相关研究的全面概述，总结了该疾病的流行病学、病因、病理生理学、临床表现、诊断和治疗方法。
