端粒酶的结构生物学及其在端粒上的相互作用。
Structural biology of telomerase and its interaction at telomeres.
机构信息
Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095-1569, USA.
Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095-1569, USA.
出版信息
Curr Opin Struct Biol. 2017 Dec;47:77-87. doi: 10.1016/j.sbi.2017.06.010. Epub 2017 Jul 18.
Abstract
Telomerase is an RNP that synthesizes the 3' ends of linear chromosomes and is an important regulator of telomere length. It contains a single long non-coding telomerase RNA (TER), telomerase reverse transcriptase (TERT), and other proteins that vary among organisms. Recent progress in structural biology of telomerase includes reports of the first cryo-electron microscopy structure of telomerase, from Tetrahymena, new crystal structures of TERT domains, telomerase RNA structures and models, and identification in Tetrahymena telomerase holoenzyme of human homologues of telomere-associated proteins that have provided a more unified view of telomerase interaction at telomeres as well as insights into the role of telomerase RNA in activity and assembly.
摘要
端粒酶是一种 RNP，可合成线性染色体的 3' 末端，是端粒长度的重要调节剂。它包含单个长的非编码端粒酶 RNA（TER）、端粒酶逆转录酶（TERT）和其他在生物体中变化的蛋白质。端粒酶结构生物学的最新进展包括首次报道了来自四膜虫的端粒酶的冷冻电镜结构、TERT 结构域的新晶体结构、端粒酶 RNA 结构和模型，以及在四膜虫端粒酶全酶中鉴定出与端粒相关的蛋白质的人类同源物，这为端粒酶在端粒上的相互作用提供了更统一的观点，也深入了解了端粒酶 RNA 在活性和组装中的作用。
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