Uysal Aysel, Alkan Gül, Kurtoğlu Ayşegül, Erol Onur, Kurtoğlu Erdal
Health Science University, Antalya Training and Research Hospital, Department of Obstetrics and Gynecology, Turkey.
Health Science University, Antalya Training and Research Hospital, Department of Obstetrics and Gynecology, Turkey.
Eur J Obstet Gynecol Reprod Biol. 2017 Sep;216:69-73. doi: 10.1016/j.ejogrb.2017.06.038. Epub 2017 Jul 5.
Iron accumulation in the endocrine glands has been implicated in the aetiopathogenesis of decreased reproductive capacity in patients with beta-thalassemia major (β-TM). The aim of the current study was to investigate the serum concentration of anti-Müllerian hormone (AMH), a marker of ovarian reserve, in women with transfusion-dependent β-TM.
In this case-control study, we recruited 43 women with transfusion-dependent TM and 44 age-matched healthy controls. Hormonal and haematological parameters, serum level of AMH, antral follicle count, and ovarian volume were assessed.
Twenty-two of the 43 women were hypogonadotropic, 8 with primary amenorrhea and 14 with secondary amenorrhea. FSH, LH, estradiol, prolactin, and AMH levels; antral follicle count; and ovarian volume were significantly lower in women with TM compared with the control group (p<0.05 for all).
AMH level and other ovarian reserve markers are significantly diminished in women with transfusion-dependent TM compared to age-matched controls. Our findings support a deleterious effect of iron overload on ovarian tissue.
内分泌腺中铁蓄积与重型β地中海贫血（β-TM）患者生殖能力下降的病因发病机制有关。本研究旨在调查依赖输血的β-TM女性中抗苗勒管激素（AMH）的血清浓度，AMH是卵巢储备的标志物。
在这项病例对照研究中，我们招募了43名依赖输血的TM女性和44名年龄匹配的健康对照者。评估了激素和血液学参数、AMH血清水平、窦卵泡计数和卵巢体积。
43名女性中有22名促性腺激素分泌不足，8名原发性闭经，14名继发性闭经。与对照组相比，TM女性的促卵泡生成素（FSH）、促黄体生成素（LH）、雌二醇、催乳素和AMH水平、窦卵泡计数和卵巢体积显著降低（所有p<0.05）。
与年龄匹配的对照组相比，依赖输血的TM女性的AMH水平和其他卵巢储备标志物显著降低。我们的研究结果支持铁过载对卵巢组织的有害作用
