Soh Derrick, Cordato Dennis J, Bleasel Andrew F, Brimage Peter, Beran Roy G
Department of Neurology, Liverpool Hospital, NSW, Australia; South Western Sydney Clinical School, University of NSW, Australia.
Department of Neurology, Westmead Hospital, Westmead, NSW, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Epilepsy Behav. 2017 Sep;74:119-123. doi: 10.1016/j.yebeh.2017.06.027. Epub 2017 Jul 18.
Rasmussen's encephalitis (RE) is a rare unilateral inflammatory brain disorder that causes progressive neurocognitive deterioration and refractory epilepsy including epilepsia partialis continua (EPC). We describe a patient with a unique presentation, where right upper limb EPC due to RE began within 2weeks of a concussive left frontal head injury, in a 36-year-old female without other identifiable etiology, no prior neurological deficit nor suggestion of intracranial pathology or infection, and no preceding seizures. The diagnosis of RE followed extensive investigation, excluding confounding diagnoses, with supportive histopathology, and her EPC has proven refractory to treatment. In the absence of a satisfactory alternative etiology and exclusion of differential diagnoses, the most likely cause or precipitant of this patient's RE was head trauma.
拉斯穆森脑炎（RE）是一种罕见的单侧炎症性脑部疾病，可导致进行性神经认知功能衰退和难治性癫痫，包括持续性部分性癫痫（EPC）。我们描述了一名具有独特表现的患者，一名36岁女性，无其他可识别病因，既往无神经功能缺损，无颅内病变或感染迹象，且无癫痫发作史，因RE导致的右侧上肢EPC在左侧额叶脑震荡性头部损伤后2周内出现。经过广泛检查，排除了混淆诊断，并通过支持性组织病理学确诊为RE，其EPC已证明对治疗难治。在没有令人满意的替代病因且排除鉴别诊断的情况下，该患者RE最可能的原因或诱因是头部创伤。
