类固醇：TBI 诱导性过度睡眠的警钟。
Steroids: A Wake-Up Call in TBI Induced Hypersomnolence.
机构信息
Lenox Hill Hospital - Northwell Health System, Department of Pulmonary, Critical Care, and Sleep Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
Cohen Children's Medical Center, Pediatric Sleep Program, Department of Pediatrics, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
出版信息
J Clin Sleep Med. 2019 Jul 15;15(7):1063-1065. doi: 10.5664/jcsm.7894.
Hypersomnolence is one of the more common symptoms reported after mild traumatic brain injury (TBI) and often one of the most difficult to treat. This case series presents a cohort of patients with TBI related hypersomnolence associated with a de novo autoimmune process that successfully resolved with pulse dose corticosteroid treatment. When associated with an autoimmune inflammatory process, corticosteroids may serve to stabilize the blood brain barrier leading to the successful and sustained resolution of TBI induced sleepiness.
嗜睡是轻度创伤性脑损伤 (TBI) 后较常见的症状之一，也是较难治疗的症状之一。本病例系列报告了一组与新出现的自身免疫过程相关的 TBI 相关嗜睡患者，这些患者经脉冲剂量皮质类固醇治疗后成功缓解。当与自身免疫炎症过程相关时，皮质类固醇可能有助于稳定血脑屏障，从而成功和持续缓解 TBI 引起的嗜睡。
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