Department of Gastroenterology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, 310009, China.
Sci Rep. 2017 Jul 21;7(1):6144. doi: 10.1038/s41598-017-06577-2.
Glasgow prognostic score (GPS) has been reported to be an indicator of prognosis for various cancers. However, the relationship between GPS and colorectal cancers (CRC) remains unclear. A comprehensive search of Pubmed, Embase, Cochrane library, Web of Science, ChinaInfo and Chinese National Knowledge Infrastructure was performed to identify eligible studies, from which the risk of overall survival (OS) and cancer-specific survival (CSS) were extracted. A random-effect model was adopted to combine hazard ratio (HR) and 95% confidence interval (CI). 25 articles with a total of 5660 participants were included. The pooled results indicated that elevated GPS was associated with poor OS (HR = 2.83, 95%CI: 2.00-4.00, P < 0.01) and CSS (HR = 1.94, 95%CI: 1.51-2.49, P < 0.01). This correlation was confirmed both in primary operable and advanced inoperable patients. Increased GPS was also closely related to advanced tumour-node-metastasis (TNM) stage (odds ratio [OR] = 1.44, 95% CI: 1.010-2.065, P < 0.05) and elevated level of serum carcinoembryonic antigen (OR = 2.252, 95% CI: 1.508-3.362, P < 0.01). Subgroup analysis revealed a significant association between high GPS and poor survival outcome according to the factors of sample size, study of region and cut-off value of GPS level. These findings suggest that GPS may serve as a reliable predictive index for patients with CRC.
格拉斯哥预后评分（GPS）已被报道可作为多种癌症预后的指标。然而，GPS 与结直肠癌（CRC）之间的关系尚不清楚。我们对 Pubmed、Embase、Cochrane 图书馆、Web of Science、中国资讯和中国国家知识基础设施进行了全面检索，以确定合格的研究，从中提取总生存（OS）和癌症特异性生存（CSS）的风险。采用随机效应模型来合并危险比（HR）和 95％置信区间（CI）。共纳入 25 篇文章，总计 5660 名参与者。汇总结果表明，升高的 GPS 与较差的 OS（HR=2.83，95％CI：2.00-4.00，P<0.01）和 CSS（HR=1.94，95％CI：1.51-2.49，P<0.01）相关。该相关性在原发性可手术和晚期不可手术患者中均得到证实。升高的 GPS 也与晚期肿瘤-淋巴结-转移（TNM）分期密切相关（比值比[OR]=1.44，95％CI：1.010-2.065，P<0.05）和血清癌胚抗原水平升高（OR=2.252，95％CI：1.508-3.362，P<0.01）。亚组分析根据样本量、研究区域和 GPS 水平截断值的因素，显示出高 GPS 与较差生存结局之间存在显著关联。这些发现表明，GPS 可能是 CRC 患者的可靠预测指标。
