Lin Mao-Song, Huang Jun-Xing, Yu Hong
Department of Gastroenterology, Taizhou People's Hospital Taizhou, Jiangsu Province, P. R. China.
Department of Oncology, Taizhou People's Hospital Taizhou, Jiangsu Province, P. R. China.
Int J Clin Exp Med. 2015 Oct 15;8(10):19138-43. eCollection 2015.
Glasgow prognostic score (GPS), one information based prognostic score, has been previously shown to be a prognostic factor in varieties cancers mostly in advanced tumors. This study aimed to explore its value in patients with relatively early stage colorectal cancer (CRC). A total of 99 CRC patients with stage II from 2005 to 2010 operated in our hospital were enrolled in this study. C-reactive protein (CRP), albumin (ALB), Karnofsky Performance Status (KPS) score as well as a variety of biochemical variables before the operation was acquired from the database retrospectively. The value of GPS was calculated and its association with the clinical factors was further investigated. The prognostic significance was analyzed by univariate and multivariate analyses. Increased preoperative GPS was found associated with elevated carcinoembryonic antigen (CEA) and decreasing of KPS. Kaplan-Meier analysis and log-rank test revealed that a higher GPS predicted a higher risk of postoperative mortality in stage II CRC (P < 0.001). Furthermore, multivariate analysis demonstrated the GPS to be a risk factor for postoperative mortality (HR 3.215; P=0.025). The preoperative GPS might be a potential useful indicator for postoperative survival in patients with stage II CRC.
格拉斯哥预后评分（GPS）是一种基于信息的预后评分，此前已被证明是多种癌症（主要是晚期肿瘤）的预后因素。本研究旨在探讨其在相对早期结直肠癌（CRC）患者中的价值。本研究纳入了2005年至2010年在我院接受手术的99例II期CRC患者。回顾性地从数据库中获取术前的C反应蛋白（CRP）、白蛋白（ALB）、卡诺夫斯基功能状态（KPS）评分以及各种生化变量。计算GPS的值，并进一步研究其与临床因素的关联。通过单因素和多因素分析来分析预后意义。发现术前GPS升高与癌胚抗原（CEA）升高和KPS降低相关。Kaplan-Meier分析和对数秩检验显示，较高的GPS预示着II期CRC患者术后死亡风险较高（P < 0.001）。此外，多因素分析表明GPS是术后死亡的危险因素（HR 3.215；P = 0.025）。术前GPS可能是II期CRC患者术后生存的一个潜在有用指标。
