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腹腔镜巨大食管裂孔疝修补术:是否存在与解剖复发相关的因素?

Laparoscopic repair of giant paraesophageal hernia: are there factors associated with anatomic recurrence?

机构信息

Department of Surgery, Mayo Clinic in Florida, Davis 3 North, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Department of Surgery, Rush University Medical Center, Chicago, IL, USA.

出版信息

Surg Endosc. 2018 Feb;32(2):945-954. doi: 10.1007/s00464-017-5770-z. Epub 2017 Jul 21.

Abstract

BACKGROUND

Repair of giant paraesophageal hernia (PEH) is associated with a favorably high rate of symptom improvement; however, rates of recurrence by objective measures remain high. Herein we analyze our experience with laparoscopic giant PEH repair to determine what factors if any can predict anatomic recurrence.

METHODS

We prospectively collected data on PEH characteristics, variations in operative techniques, and surgeon factors for 595 patients undergoing laparoscopic PEH repair from 2008 to 2015. Upper GI study was performed at 6 months postoperatively and selectively thereafter-any supra-diaphragmatic stomach was considered hiatal hernia recurrence. Exclusion criteria included revisional operation (22.4%), size <5 cm (17.6%), inadequate follow-up (17.8%), and confounding concurrent operations (6.9%). Inclusion criteria were met by 202 patients (31% male, median age 71 years, and median BMI 28.7).

RESULTS

At a median follow-up of 6 months (IQR 6-12), overall anatomic recurrence rate was 34.2%. Symptom recurrence rate was 9.9% and revisional operation was required in ten patients (4.9%). Neither patient demographics nor PEH characteristics (size, presence of Cameron erosions, esophagitis, or Barrett's) correlated with anatomic recurrence. Technical factors at operation (mobilized intra-abdominal length of esophagus, Collis gastroplasty, number of anterior/posterior stitches, use of crural buttress, use of pledgeted or mattress sutures, or gastrostomy) were also not correlated with recurrence. Regarding surgeon factors, annual volume of fewer than ten cases per year was associated with increased risk of anatomic failure (54 vs 33%, P = 0.02). Multivariate analysis identified surgeon experience (<10 cases per year) as an independent factor associated with early hiatal hernia recurrence (OR 3.7, 95% CI 1.34-10.9).

CONCLUSIONS

Laparoscopic repair of giant PEH is associated with high anatomic recurrence rate but excellent symptom control. PEH characteristics and technical operative variables do not appear to significantly affect rates of recurrence. In contrast, surgeon volume does appear to contribute significantly to durability of repair.

摘要

背景

巨大食管裂孔疝(PEH)的修补术与症状改善的高几率相关;然而,客观测量的复发率仍然很高。在此,我们分析腹腔镜治疗巨大食管裂孔疝的经验,以确定哪些因素(如果有的话)可以预测解剖复发。

方法

我们前瞻性地收集了 2008 年至 2015 年间 595 例接受腹腔镜食管裂孔疝修补术患者的 PEH 特征、手术技术变化和外科医生因素的数据。术后 6 个月进行上消化道研究,此后选择性进行——任何膈上胃均被认为是食管裂孔疝复发。排除标准包括翻修手术(22.4%)、疝口<5cm(17.6%)、随访不足(17.8%)和并发的合并手术(6.9%)。符合纳入标准的患者为 202 例(31%为男性,中位年龄 71 岁,中位 BMI 为 28.7)。

结果

中位随访 6 个月(IQR 6-12),总体解剖复发率为 34.2%。症状复发率为 9.9%,10 例患者需要再次手术(4.9%)。患者人口统计学特征和 PEH 特征(大小、是否存在 Cameron 侵蚀、食管炎或 Barrett 食管)与解剖复发均无相关性。术中技术因素(游离腹腔内食管长度、Collis 胃成形术、前/后缝线数量、使用胃底加固、使用带垫片或褥式缝线、或胃造口术)也与复发无关。关于外科医生因素,每年手术量少于 10 例与解剖失败风险增加相关(54% vs 33%,P=0.02)。多因素分析确定外科医生经验(每年少于 10 例)是与早期食管裂孔疝复发相关的独立因素(OR 3.7,95%CI 1.34-10.9)。

结论

腹腔镜治疗巨大食管裂孔疝与高解剖复发率相关,但症状控制良好。PEH 特征和技术操作变量似乎并未显著影响复发率。相比之下,外科医生手术量确实对修复的耐久性有显著影响。

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