肠病负担与“亚临床”感染
The Burden of Enteropathy and "Subclinical" Infections.
作者信息
Rogawski Elizabeth T, Guerrant Richard L
机构信息
Department of Public Health Sciences, University of Virginia, PO Box 801379, Carter Harrison Research Building MR-6, 345 Crispell Drive, Room 2520, Charlottesville, VA 22908-1379, USA; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, PO Box 801379, Carter Harrison Research Building MR-6, 345 Crispell Drive, Room 2520, Charlottesville, VA 22908-1379, USA.
Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, PO Box 801379, Carter Harrison Research Building MR-6, 345 Crispell Drive, Room 2520, Charlottesville, VA 22908-1379, USA.
出版信息
Pediatr Clin North Am. 2017 Aug;64(4):815-836. doi: 10.1016/j.pcl.2017.03.003.
Abstract
Environmental enteropathy is a chronic condition of the small intestine associated with increased intestinal permeability, mucosal inflammation, malabsorption, and systemic inflammation. It is commonly accompanied by enteric infections and is misleadingly considered a subclinical disease. Potential effects of enteric infections and enteropathy on vaccine responses, child growth, cognitive development, and even later life obesity, diabetes, and metabolic syndrome are increasingly being recognized. Herein, we review the evolving challenges to defining environmental enteropathy and enteric infections, current evidence for the magnitude and determinants of its burden, new assessment tools, and relevant interventions.
摘要
环境性肠病是一种小肠的慢性病症，与肠道通透性增加、黏膜炎症、吸收不良和全身炎症相关。它通常伴有肠道感染，且被错误地认为是一种亚临床疾病。肠道感染和肠病对疫苗反应、儿童生长、认知发育乃至后期生活中的肥胖、糖尿病和代谢综合征的潜在影响正日益受到认可。在此，我们综述了在定义环境性肠病和肠道感染方面不断演变的挑战、其负担程度和决定因素的现有证据、新的评估工具以及相关干预措施。
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