Sun Yongjun, Liu Kevin, Martinez Erik, Dale Jahrane, Huang Dong, Wang Jing
Department of Anesthesiology, Hunan Cancer Hospital, Hunan Provence, China.
Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, NY, 10016, United States.
Behav Brain Res. 2017 Sep 15;334:1-5. doi: 10.1016/j.bbr.2017.07.020. Epub 2017 Jul 19.
Glutamate signaling in the central nervous system is known to play a key role in pain regulation. AMPAkines can enhance glutamate signaling through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. previous studies have shown that AMPAkines are effective analgesic agents, and their site of action is likely in the brain. It is not known, however, if AMPAkines can provide complementary analgesia in combination with opioids, the most commonly used analgesics. Here, we show that the co-administration of an AMPAkine with morphine can provide additional analgesia, both in naïve rats and in rats that experience postoperative pain. Furthermore, we show that this AMPAkine can be administered directly into the prefrontal cortex to provide analgesia, and that prefrontal AMPAkine infusion, similar to systemic administration, can provide added pain relief to complement morphine analgesia.
已知谷氨酸信号传导在中枢神经系统的疼痛调节中起关键作用。AMPA 受体激动剂可通过α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体增强谷氨酸信号传导。先前的研究表明，AMPA 受体激动剂是有效的镇痛剂，其作用部位可能在大脑。然而，尚不清楚 AMPA 受体激动剂与最常用的镇痛药阿片类药物联合使用时是否能提供互补性镇痛作用。在此，我们表明，在未处理的大鼠和经历术后疼痛的大鼠中，将一种 AMPA 受体激动剂与吗啡联合给药均可提供额外的镇痛效果。此外，我们还表明，这种 AMPA 受体激动剂可直接注入前额叶皮质以提供镇痛作用，并且与全身给药类似，前额叶注入 AMPA 受体激动剂可提供额外的疼痛缓解，以补充吗啡镇痛作用。
