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[新生儿传统药物严重中毒]

[Severe poisoning by traditional medication in the newborn].

作者信息

Oulmaati A, Hmami F, Achour S, Bouharrou A

机构信息

Faculté de médecine et pharmacie de Tanger, université Abdelmalek Essaadi, Tanger, Maroc.

Service de néonatologie et réanimation néonatale, faculté de médecine et pharmacie de Fès, université sidi Mohammed ben Abdallah, CHU Hassan II Fès, Fès, Maroc.

出版信息

Arch Pediatr. 2017 Sep;24(9):833-836. doi: 10.1016/j.arcped.2017.06.005. Epub 2017 Jul 19.

Abstract

The use of traditional products for therapeutic purposes in the newborn cause many cases of severe poisoning, especially in newborns. The aim of this study was to identify the main medicinal plants causing poisoning and emphasize the seriousness of poisonous plants. We report a series of eight newborns admitted for intake of poisonous medicinal plants admitted to the neonatal unit and neonatal intensive care unit at the Fez (Morocco) Hassan II University Hospital in 2014. The reasons for use were dominated by the infant's refusing to suckle. Clinical signs at admission were neurological signs and respiratory distress. The decision was spontaneously declared by the family for only two patients. A particular smell of the urine and unusual lesion associations were the main signs drawing the attention of physicians in other cases. The amounts and rates differed. Laboratory tests revealed renal failure in two cases. Transaminases (SGOT and SGPT) were greater than three times normal and the TP was below 50% in two newborns. Hemoglobin less than 9g/dL in three cases and thrombocytopenia less than 50,000/mm in two newborns. The main poisonous plants were identified as cade oil and henna. Medicinal plants were associated in all cases. Toxicological analysis was negative in three cases and was not done in the other five cases. The management was symptomatic and etiological. The outcome was favorable in six newborns. Death occurred in two neonates despite resuscitation. Medicinal plants must, like drugs, obey strict rules that only the standard herbal medicine specialist can answer. This necessarily involves the regulation of the profession in our country.

摘要

在新生儿中使用传统产品用于治疗目的导致了许多严重中毒病例,尤其是在新生儿中。本研究的目的是确定导致中毒的主要药用植物,并强调有毒植物的严重性。我们报告了2014年在摩洛哥非斯哈桑二世大学医院新生儿科和新生儿重症监护病房收治的一系列8例因摄入有毒药用植物而入院的新生儿。使用的原因主要是婴儿拒乳。入院时的临床症状为神经症状和呼吸窘迫。只有两名患者是由家属自发声明的。在其他病例中,尿液的特殊气味和异常的病变关联是引起医生注意的主要迹象。用量和比例各不相同。实验室检查显示两例出现肾衰竭。两名新生儿的转氨酶(谷草转氨酶和谷丙转氨酶)高于正常水平三倍以上,总蛋白低于50%。三例血红蛋白低于9g/dL,两例新生儿血小板减少低于50,000/mm³。主要的有毒植物被确定为杜松油和指甲花。所有病例中都使用了药用植物。三例毒理学分析为阴性,其他五例未进行毒理学分析。治疗方法是对症和病因治疗。六名新生儿预后良好。尽管进行了复苏,仍有两名新生儿死亡。药用植物必须像药物一样,遵守只有正规草药专家才能解答的严格规定。这必然涉及我国对该行业的监管。

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