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来自皮肤涂抹杜松油的致命新生儿中毒:一例多脏器衰竭病例

Fatal Neonatal Intoxication From Cutaneous Cade Oil: A Case of Multivisceral Failure.

作者信息

Chaïmae Salhi, Ech-Chebab Mohammed, Ayyad Anass, Messaoudi Sahar, Amrani Rim

机构信息

Department of Neonatology and Intensive Care Unit, Mohammed VI University Hospital of Oujda, Faculty of Medicine and Pharmacy of Oujda, University Mohammed First of Oujda, Maternal Child and Mental Health Research Laboratory of Oujda, Oujda, MAR.

出版信息

Cureus. 2024 Jul 22;16(7):e65133. doi: 10.7759/cureus.65133. eCollection 2024 Jul.

DOI:10.7759/cureus.65133
PMID:39171036
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11338636/
Abstract

is a plant whose branches and wood are used to extract cade oil. This oil is widely used in traditional Moroccan medicine for its analgesic, digestive, bronchopulmonary, and dermatological properties. However, it contains toxic phenols like guaiacol and cresol, which can cause serious side effects across various organ systems, including renal, hepatic, cardiac, pulmonary, neurological, gastrointestinal, dermatological, hematological, and metabolic. We report the case of a newborn hospitalized in neonatal intensive care at Mohammed VI University Hospital in Oujda, Morocco, following cutaneous exposure to cade oil. The newborn was admitted with acute cardiovascular shock, rapidly progressing to multiorgan failure. Despite intensive resuscitation measures, the patient died on the second day of hospitalization.

摘要

是一种其树枝和木材用于提取杜松油的植物。这种油因其止痛、消化、支气管肺部和皮肤病学特性而在传统摩洛哥医学中广泛使用。然而,它含有如愈创木酚和甲酚等有毒酚类物质,可在包括肾脏、肝脏、心脏、肺部、神经、胃肠道、皮肤、血液和代谢等各个器官系统中引起严重副作用。我们报告了一名新生儿的病例,该新生儿在摩洛哥乌季达穆罕默德六世大学医院新生儿重症监护病房住院,此前皮肤接触了杜松油。该新生儿因急性心血管休克入院,迅速发展为多器官功能衰竭。尽管采取了强化复苏措施,患者仍在住院第二天死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a09/11338636/67a07786f0ca/cureus-0016-00000065133-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a09/11338636/67a07786f0ca/cureus-0016-00000065133-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a09/11338636/67a07786f0ca/cureus-0016-00000065133-i01.jpg

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本文引用的文献

1
A rare case of cade oil poisoning complicated by acute pancreatitis and acute tubular necrosis.一例罕见的蓖麻油中毒合并急性胰腺炎和急性肾小管坏死病例。
Ann Med Surg (Lond). 2022 Apr 4;76:103562. doi: 10.1016/j.amsu.2022.103562. eCollection 2022 Apr.
2
Treating infants with frigg: linking disease aetiologies, medicinal plant use and care-seeking behaviour in southern Morocco.用弗里格治疗婴儿:摩洛哥南部疾病病因、药用植物使用与就医行为的关联
J Ethnobiol Ethnomed. 2017 Jan 13;13(1):4. doi: 10.1186/s13002-016-0129-4.
3
Side effects of cade oil in Morocco: an analysis of reports in the Moroccan herbal products database from 2004 to 2012.
摩洛哥卡德油的副作用:对 2004 年至 2012 年摩洛哥草药产品数据库报告的分析。
Food Chem Toxicol. 2014 Feb;64:81-5. doi: 10.1016/j.fct.2013.11.009. Epub 2013 Nov 20.
4
Juniper tar (cade oil) poisoning in new born after a cutaneous application.新生儿皮肤涂抹杜松焦油(杜松油)后中毒
BMJ Case Rep. 2011 Oct 28;2011:bcr0720114427. doi: 10.1136/bcr.07.2011.4427.
5
Essential oil poisoning: N-acetylcysteine for eugenol-induced hepatic failure and analysis of a national database.精油中毒:N-乙酰半胱氨酸治疗丁香酚诱导的肝衰竭及国家数据库分析
Eur J Pediatr. 2005 Aug;164(8):520-2. doi: 10.1007/s00431-005-1692-1. Epub 2005 May 14.
6
Juniper tar poisoning.
Clin Toxicol (Phila). 2005;43(1):47-9. doi: 10.1081/clt-45072.
7
Marked increases of aminotransferase levels after cresol ingestion.摄入甲酚后转氨酶水平显著升高。
Am J Emerg Med. 1998 Nov;16(7):667-8. doi: 10.1016/s0735-6757(98)90171-1.