Baggio B, Briani G, Cicerello E, Gambaro G, Bruttomesso D, Tiengo A, Borsatti A, Crepaldi G
Nephron. 1986;43(3):187-90. doi: 10.1159/000183827.
Urinary excretion of glycosaminoglycans (GAGS) and sialic acid (SA), as well as the activity of two renal enzymes related to glycoprotein metabolism, N-acetyl-beta-D-glucosaminidase (NAG) and beta-galactosidase (GAL), and two others unrelated to glycosaminoglycans and glycoprotein metabolism, gamma-glutamyltranspeptidase (gamma-Gt) and angiotensin-I-converting enzyme (ACE), were evaluated in 40 insulin-dependent diabetic patients with normal range albuminuria, 21 patients with mesangial glomerulonephritis, and 30 control subjects. Diabetic and glomerulonephritic patients excreted a significantly higher amount of GAGS and SA, and showed greater NAG and GAL activities; gamma-Gt and ACE levels were within normal ranges. No correlation could be demonstrated between diabetes duration and GAGS, SA, NAG and GAL findings. Moreover, no correspondence between degree of metabolic control, as reflected by glycosylated hemoglobin (HbA1a-c) and GAGS, SA, NAG and GAL emerged.
在40例白蛋白尿范围正常的胰岛素依赖型糖尿病患者、21例系膜增生性肾小球肾炎患者及30例对照者中，对糖胺聚糖（GAGS）、唾液酸（SA）的尿排泄，以及与糖蛋白代谢相关的两种肾酶即N-乙酰-β-D-氨基葡萄糖苷酶（NAG）和β-半乳糖苷酶（GAL），以及另外两种与糖胺聚糖和糖蛋白代谢无关的酶即γ-谷氨酰转肽酶（γ-Gt）和血管紧张素I转换酶（ACE）的活性进行了评估。糖尿病患者和肾小球肾炎患者排泄的GAGS和SA量显著更高，且NAG和GAL活性更强；γ-Gt和ACE水平在正常范围内。糖尿病病程与GAGS、SA、NAG和GAL的检测结果之间未显示出相关性。此外，糖化血红蛋白（HbA1a-c）所反映的代谢控制程度与GAGS、SA、NAG和GAL之间也未出现对应关系。
