Biotransformation of amitriptyline in man: interaction with phenothiazines.
作者信息
Vandel S, Sandoz M, Vandel B, Bonin B, Allers G, Volmat R
出版信息
Neuropsychobiology. 1986;15(1):15-9. doi: 10.1159/000118235.
PMID:2873526
Abstract
The biotransformation modification of amitriptyline by phenothiazines has been studied in 65 depressive inpatients. Thirty-four of them were treated with oral amitriptyline and 31 with a combination of amitriptyline and phenothiazine. Urinary and plasmatic results showed a decrease in hydroxylated metabolites of amitriptyline (OHAMTc and OHAMT) in patients with added phenothiazine.
摘要
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