Breyer-Pfaff U, Ewert M, Wiatr R
Arzneimittelforschung. 1978;28(10b):1916-20.
Plasma drug levels and urinary metabolites were measured in a volunteer for 28 h after ingestion of amitriptyline hydrochloride or amitriptyline N-oxide (amitriptylinoxide) equivalent to 100 mg of amitriptyline base. The N-oxide initially produced high plasma levels and 15% of the dose was excreted unchanged within 14 h. From comparison of the metabolite excretions, it can be concluded that about 70% of the dose was reduced at the N-oxide group, while comparison of the areas under the plasma group, while comparison of the areas under the plasma level-time curves for amitriptyline pointed to a 55% reduction to the amine. Less drowsiness was experienced after ingesting the N-oxide, and there was no depressive mood.
在一名志愿者摄入相当于100毫克阿米替林碱的盐酸阿米替林或N-氧化阿米替林（阿米替林氧化物）后，对其血浆药物水平和尿液代谢物进行了28小时的测量。N-氧化物最初产生较高的血浆水平，14小时内15%的剂量以原形排出。通过比较代谢物排泄情况可以得出结论，N-氧化物组约70%的剂量被还原，而比较血浆水平-时间曲线下的面积，阿米替林组则显示胺类减少了55%。摄入N-氧化物后嗜睡感较轻，且没有抑郁情绪。
