Shao M, Ming Y, Cheng K, Yang M, Ye Q
Transplantation Surgery Center, Third Xiangya Hospital, Central South University, Changsha, China.
Transplantation Surgery Center, Third Xiangya Hospital, Central South University, Changsha, China.
Transplant Proc. 2017 Jul-Aug;49(6):1276-1279. doi: 10.1016/j.transproceed.2017.03.077.
Shortage of donors still is the major obstacle for kidney transplantation. Living-related donors are the major resource of kidney transplantation at present. To expand the donor pool, spousal-donor kidney transplantation as one of the types of living-unrelated donors has been used to alleviate the organ shortage. A total of 116 living-kidney transplantations were retrospectively analyzed. We classified these recipients into two groups: a spousal-donor group (n = 50) and a living-related donor group (n = 66), and analyzed the outcome of transplantation. The Kaplan-Meier method was used for survival analysis with the log-rank test. The occurrence of delayed graft function and biopsy-proven acute rejection showed no significant difference between the two groups. Serum creatinine values at different times after transplantation in recipients with functioning grafts were similar in the two groups. Kaplan-Meier 3-year patient and graft survival rates were, respectively, 98% and 94% for the spousal donor group, and 98.5% and 95.5% for living-related donor group without significant difference. The demonstration of similar patient and graft survival of spousal-donor kidney transplantation compared with living-related donor kidney transplantation has made spousal-donor kidney transplantation an acceptable alternative for donor supply.
供体短缺仍然是肾移植的主要障碍。亲属活体供体是目前肾移植的主要供体来源。为了扩大供体库，配偶活体供肾移植作为非亲属活体供体的一种类型，已被用于缓解器官短缺问题。我们对116例活体肾移植进行了回顾性分析。我们将这些受者分为两组：配偶供体组（n = 50）和亲属活体供体组（n = 66），并分析了移植结果。采用Kaplan-Meier法进行生存分析，并进行对数秩检验。两组之间移植肾功能延迟恢复的发生率和活检证实的急性排斥反应发生率无显著差异。两组中移植肾功能良好的受者移植后不同时间的血清肌酐值相似。配偶供体组的Kaplan-Meier 3年患者和移植物生存率分别为98%和94%，亲属活体供体组为98.5%和95.5%，差异无统计学意义。与亲属活体供肾移植相比，配偶活体供肾移植患者和移植物生存率相似，这使得配偶活体供肾移植成为一种可接受的供体来源选择。
