Department of Materials Science and Engineering, University of Maryland College Park, College Park, Maryland 20742, USA.
Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Nat Commun. 2017 Jul 24;8:15609. doi: 10.1038/ncomms15609.
In a lithium-ion battery, electrons are released from the anode and go through an external electronic circuit to power devices, while ions simultaneously transfer through internal ionic media to meet with electrons at the cathode. Inspired by the fundamental electrochemistry of the lithium-ion battery, we envision a cell that can generate a current of ions instead of electrons, so that ions can be used for potential applications in biosystems. Based on this concept, we report an 'electron battery' configuration in which ions travel through an external circuit to interact with the intended biosystem whereas electrons are transported internally. As a proof-of-concept, we demonstrate the application of the electron battery by stimulating a monolayer of cultured cells, which fluoresces a calcium ion wave at a controlled ionic current. Electron batteries with the capability to generate a tunable ionic current could pave the way towards precise ion-system control in a broad range of biological applications.
在锂离子电池中，电子从阳极释放出来，通过外部电子电路为设备供电，同时离子通过内部离子介质同时转移，以在阴极与电子相遇。受锂离子电池基本电化学原理的启发，我们设想了一种可以产生离子电流而不是电子电流的电池，以便离子可以用于生物系统中的潜在应用。基于这一概念，我们报告了一种“电子电池”结构，其中离子通过外部电路传输以与预期的生物系统相互作用，而电子则在内部传输。作为概念验证，我们通过刺激单层培养细胞来演示电子电池的应用，该细胞在受控的离子电流下发出钙离子波荧光。具有产生可调离子电流能力的电子电池可以为广泛的生物应用中精确的离子系统控制铺平道路。
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