From the Departments of *Oncology, †Pathology, and ‡Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark.
Clin Nucl Med. 2017 Oct;42(10):790-792. doi: 10.1097/RLU.0000000000001773.
Ga-PSMA PET/CT was performed in a 75-year-old man with newly diagnosed prostate cancer because of an equivocal lesion in the spine both on Tc-bone-SPECT/CT and MRI. Because of increased PSMA activity on PET/CT, the bone lesion was interpreted as metastasis from prostate cancer. Later, the patient was diagnosed as having monoclonal gammopathy of unknown significance. A biopsy was performed, and histological examination revealed multiple myeloma with PSMA expression in the neovessels but no metastatic prostate cancer cells. The patient was downstaged, and the treatment was changed accordingly. This case illustrates the importance of biopsies from PSMA PET-positive lesions.
Ga-PSMA PET/CT 检查在一名 75 岁男性中进行，该男性新诊断为前列腺癌，原因是 Tc-骨 SPECT/CT 和 MRI 上脊柱的可疑病变。由于 PET/CT 上 PSMA 活性增加，骨病变被解释为前列腺癌转移。后来，该患者被诊断为意义未明的单克隆丙种球蛋白病。进行了活检，组织学检查显示多发性骨髓瘤，新血管中有 PSMA 表达，但没有转移性前列腺癌细胞。患者降期，治疗相应改变。本病例说明了对 PSMA PET 阳性病变进行活检的重要性。
