Bentestuen Morten, Elkjær Maria Carlsen, Zacho Helle D
Department of Nuclear Medicine, Aalborg University Hospital, Aalborg, Denmark.
Department of Urology, Aalborg University Hospital, Aalborg, Denmark.
World J Nucl Med. 2022 Dec 20;22(1):67-69. doi: 10.1055/s-0042-1758805. eCollection 2023 Mar.
Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography ( Ga PSMA PET/CT) outperforms CT and bone scintigraphy in terms of diagnostic accuracy for the primary staging of prostate cancer and has become widely used. However, Ga PSMA uptake is also encountered in nonprostatic tissue. We present a 63-year-old male with newly diagnosed high-risk prostate cancer who underwent bone scintigraphy with single-photon emission computed tomography/computed tomography (SPECT/CT), which showed inhomogeneous elevated uptake in sclerotic bone lesions in the pelvis. Likewise, Ga PSMA PET/CT revealed inhomogeneous uptake in the same areas. Subsequent biopsy revealed hyperplastic bone marrow without signs of malignancy. The patient underwent radical prostatectomy, and the prostate-specific antigen level dropped to less than 0.1 ng/mL.
镓-68前列腺特异性膜抗原正电子发射断层扫描/计算机断层扫描（Ga PSMA PET/CT）在前列腺癌原发分期的诊断准确性方面优于CT和骨闪烁显像，并且已得到广泛应用。然而，在非前列腺组织中也会出现Ga PSMA摄取。我们报告一名63岁新诊断为高危前列腺癌的男性患者，其接受了单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）骨闪烁显像，结果显示骨盆硬化性骨病变处摄取不均匀增加。同样，Ga PSMA PET/CT也显示相同区域摄取不均匀。随后的活检显示为增生性骨髓，无恶性迹象。该患者接受了根治性前列腺切除术，前列腺特异性抗原水平降至低于0.1 ng/mL。
