Liu H F, Li F, Wang Y H, Chen J H, Peng D X, Chen J, Tan L H, Mi X, Zhao B H
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Department of Epidemiology, School of Public Health, Xiamen University, Xiamen 361102, China.
Department of Health Examination, Lianhua Hospital, Xiamen 361009, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Jul 10;38(7):889-892. doi: 10.3760/cma.j.issn.0254-6450.2017.07.008.
To understand the association between peripheral leukocytes telomere length (TL) and sleep in middle-aged and old adults. A total of 176 middle-aged and old adults were investigated by using the Pittsburgh Sleep Quality Index and questionnaire. TL was measured by fluorescence quantitative PCR. The correlation and regression analysis between sleep and telomere length was performed. TL had a mean T/S ratio of 0.995±0.23. There was a negative correlation between TL and age (=-0.241, =0.003). With increasing age, sleep quality became worse (=-0.230, <0.01), the time to fall asleep became longer (=0.227, <0.01), sleep duration was shorter (=-0.486, <0.01), sleep efficiency became worse (=-0.226, <0.01). After controlling for the effects of gender, age, marital status, income level, residence, smoking, drinking, physical exercise and disease status, multiple linear regression analysis indicated that sleep quality (=0.057, <0.01), time to fall asleep (=-0.046, <0.01), sleep duration (=0.086, <0.01) were independent influencing factors of telomere length, suggesting that the people who had better sleep quality, the shorter time to fall asleep, the longer sleep time would have longer telomere length. Sleep is a relevant factor affecting TL in middle-aged and elderly population. Good sleep may delay aging by slowing TL. We encourage to conduct health education about the importance of sleep quality in community.
了解中老年人群外周血白细胞端粒长度（TL）与睡眠之间的关联。采用匹兹堡睡眠质量指数和问卷对176名中老年人群进行调查。通过荧光定量PCR测量端粒长度。对睡眠与端粒长度进行相关性和回归分析。端粒长度的平均T/S比值为0.995±0.23。端粒长度与年龄呈负相关（=-0.241，=0.003）。随着年龄增长，睡眠质量变差（=-0.230，<0.01），入睡时间变长（=0.227，<0.01），睡眠时间缩短（=-0.486，<0.01），睡眠效率变差（=-0.226，<0.01）。在控制性别、年龄、婚姻状况、收入水平、居住情况、吸烟、饮酒、体育锻炼和疾病状态的影响后，多元线性回归分析表明睡眠质量（=0.057，<0.01）、入睡时间（=-0.046，<0.01）、睡眠时间（=0.086，<0.01）是端粒长度的独立影响因素，提示睡眠质量越好、入睡时间越短、睡眠时间越长的人群端粒长度越长。睡眠是影响中老年人群端粒长度的相关因素。良好的睡眠可能通过减缓端粒长度缩短来延缓衰老。我们鼓励在社区开展关于睡眠质量重要性的健康教育。
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