Lang Zhiqiang, Wu Yanqiu, Li Cuiyan, Li Xinna, Wang Xuan, Qu Guimei
Department of Pathology, Yuhuangding Hospital of Qingdao University, Yantai, P.R. China.
Department of Medicine, Yuhuangding Hospital of Qingdao University, Yantai, P.R. China.
Anticancer Res. 2017 Aug;37(8):4593-4598. doi: 10.21873/anticanres.11858.
BACKGROUND/AIM: There are still many questions that surround multifocal or multicentric breast carcinoma (MMBC). The aim of this study was to analyze the clinicopathological characteristics of MMBC and provide feasible suggestions for therapy.
A total of 156 cases of MMBC in 3,597 invasive ductal breast carcinomas were collected and reviewed. Some factors related with prognosis such as tumor size, lymph node metastasis and others were assessed in each tumor focus, and mismatches among foci were recorded.
The majority of MMBC had aggregate dimensions over 2 cm (85.90%). The rate of axillary lymph node metastasis was 56.41% (88/156) compared to unifocal tumors of 33.01% (1,136/3,441). Most cases had higher Ki-67 proliferative indices (91/156). Mismatches in ER status were present in 6 cases, PR in 4 cases, proliferative index (Ki-67) in 9 cases and HER2-positive status in 2 cases.
The larger aggregate dimension of tumor, the higher metastatic rate of axillary lymph node and the high Ki-67 proliferative index seen in most cases, suggest that MMBC is biologically more aggressive than unifocal breast cancer. In addition, every focus should be tested owing to the existence of different expressions of immunostaining between foci.
背景/目的：多灶性或多中心性乳腺癌（MMBC）仍存在许多问题。本研究旨在分析MMBC的临床病理特征，并为治疗提供可行建议。
收集并回顾了3597例浸润性导管癌中的156例MMBC病例。对每个肿瘤病灶评估一些与预后相关的因素，如肿瘤大小、淋巴结转移等，并记录病灶间的不一致情况。
大多数MMBC的总体积超过2 cm（85.90%）。腋窝淋巴结转移率为56.41%（88/156），而单灶性肿瘤为33.01%（1136/3441）。大多数病例的Ki-67增殖指数较高（91/156）。ER状态不一致的有6例，PR为4例，增殖指数（Ki-67）为9例，HER2阳性状态为2例。
大多数病例中肿瘤总体积较大、腋窝淋巴结转移率较高以及Ki-67增殖指数较高，提示MMBC在生物学上比单灶性乳腺癌更具侵袭性。此外，由于病灶间免疫染色存在不同表达，每个病灶都应进行检测。
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