多灶性和多中心性乳腺癌的现有认识和显著特征。
Current understanding and distinct features of multifocal and multicentric breast cancers.
机构信息
Department of Biology, University of Dayton, Dayton, Ohio, USA.
出版信息
Cancer Rep (Hoboken). 2023 Sep;6(9):e1851. doi: 10.1002/cnr2.1851. Epub 2023 Jun 22.
BACKGROUND
Multifocal (MF) and multicentric (MC) breast cancers are referred to as synchronous, multiple ipsilateral breast cancers; however, the definitions vary among the literature, which has made understanding and analyzing these diseases challenging.
RECENT FINDINGS
The incidence ranges from 1% to 60%, with a higher prevalence in pre-menopausal women. MF and MC breast cancers, compared with unifocal breast cancers, tend to be more aggressive and are associated with lower survival rates, higher recurrence, and lymph node metastasis. Typically, patients with MF/MC breast cancers are treated with radical surgery, while breast conservation therapy may also be considered. Investigations have focused on elucidating the distinct biological features of MF/MC breast cancers, including the clonality of the cancers, the genetic alterations, and the impact of these features on disease aggressiveness and patient prognosis.
CONCLUSION
These findings will broaden the understanding of these breast cancer subtypes and aid in the development of more tailored treatment plans for patients.
背景
多灶性（MF）和多中心性（MC）乳腺癌被称为同步性、同侧多灶性乳腺癌；然而，文献中的定义各不相同，这使得理解和分析这些疾病具有挑战性。
最近的发现
其发病率范围为 1%至 60%，在绝经前妇女中更为常见。与单灶性乳腺癌相比，MF 和 MC 乳腺癌往往更具侵袭性，并且与生存率降低、更高的复发率和淋巴结转移相关。通常，MF/MC 乳腺癌患者接受根治性手术治疗，也可考虑保乳治疗。研究集中于阐明 MF/MC 乳腺癌的独特生物学特征，包括癌症的克隆性、遗传改变，以及这些特征对疾病侵袭性和患者预后的影响。
结论
这些发现将拓宽对这些乳腺癌亚型的理解，并有助于为患者制定更具针对性的治疗计划。
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