Halling H
Ann N Y Acad Sci. 1979 May 31;320:426-35.
Retrospective studies, performed in 6 hospitals in Sweden, demonstrated that severe congenital malformations occurred more frequently in neonates born to mothers who used hexachlorophene soaps, 10--60 times a day by handwashing and hand-creams during at least the first trimester of pregnancy (25 severe malformations in 460 neonates), when compared to neonates born to similarly employed mothers who did not use hexachlorophene soaps (0 severe malformations in 233 neonates). Minor congenital anomalies were also more commonly noted in the hexachlorophene-exposed group when contrasted with controls. Other known adverse influences, such as age, infections during pregnancy, other drug usage, or smoking habits did not appear different in the two groups.
在瑞典6家医院开展的回顾性研究表明，在孕期至少头三个月每天使用六氯酚肥皂洗手和涂抹护手霜10至60次的母亲所生新生儿中，严重先天性畸形的发生率更高（460例新生儿中有25例严重畸形），而在从事类似工作但未使用六氯酚肥皂的母亲所生新生儿中（233例新生儿中无严重畸形）则不然。与对照组相比，接触六氯酚的组中轻微先天性异常也更常见。两组在其他已知不良影响方面，如年龄、孕期感染、其他药物使用或吸烟习惯等，并无差异。
