Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Department of Pediatrics, Chang Gung University, Taoyuan, Taiwan.
Sci Rep. 2017 Jul 24;7(1):6314. doi: 10.1038/s41598-017-06815-7.
The raised-volume rapid thoracoabdominal compression (RVRTC) manoeuvre has been applied to obtain full forced expiratory flow-volume curves in infants. No reference data are available for Asian populations. This study was conducted to establish predictive reference equations for Taiwanese infants. Full-term infants without any chronic disease or major anomaly were enrolled from this cohort study. Full forced expiratory flow-volume curves were acquired using RVRTC manoeuvres through Jaeger's system. Tidal breath analysis, passive respiratory mechanics, and tidal forced expiratory flow-volume curves were performed and collected at the same measurement. Multiple linear analyses were used to model the variables. We performed 117 tests of RVRTC flow-volume curves in 97 infants. The results revealed that all parameters, except for FEV /FVC, correlated highly and positively with body length. These parameters correlated significantly with other parameters of passive respiratory mechanics and tidal forced expiratory flow-volume curves. This is the first study to establish equipment-specific reference data of full forced expiration using RVRTC manoeuvres in Asian infants. The results revealed that parameters of RVRTC manoeuvres are moderately related to other parameters of infant lung function. These race-specific reference data can be used to more precisely and efficiently diagnose respiratory diseases in infants of Chinese ethnicity.
升容积快速胸腹部压缩（RVRTC）手法已被应用于获取婴儿完全用力呼气流量-容积曲线。亚洲人群尚无参考数据。本研究旨在为台湾婴儿建立预测参考方程。本队列研究纳入了无任何慢性疾病或重大异常的足月婴儿。通过 Jaeger 系统进行 RVRTC 手法获取完全用力呼气流量-容积曲线。在同一测量中进行潮气呼吸分析、被动呼吸力学和潮气用力呼气流量-容积曲线。使用多元线性分析来对变量进行建模。我们对 97 名婴儿的 117 次 RVRTC 流量-容积曲线测试进行了分析。结果表明，除 FEV/FVC 外，所有参数均与身长高度相关且呈正相关。这些参数与被动呼吸力学和潮气用力呼气流量-容积曲线的其他参数显著相关。这是第一项在亚洲婴儿中使用 RVRTC 手法建立全用力呼气设备特定参考数据的研究。结果表明，RVRTC 手法的参数与婴儿肺功能的其他参数中度相关。这些特定种族的参考数据可更精确、高效地诊断华裔婴儿的呼吸疾病。
