Yang Lixia, Xiao Juan, Wang Jiawei, Zhang Han
Department of Ophthalmology, The Second Hospital of Shandong University, Jinan, Shandong, China.
Center of Evidence-Based Medicine, The Second Hospital of Shandong University, Jinan, Shandong, China.
J Ophthalmol. 2017;2017:8978527. doi: 10.1155/2017/8978527. Epub 2017 Jun 27.
To investigate the clinical characteristics of Mooren's ulcer in East China and to identify the potential risk factors that affect the recurrence of Mooren's ulcer.
We reviewed the medical records of 95 patients (100 eyes) diagnosed with Mooren's ulcer from May 2005 to December 2014. The patients were classified into recurrent and nonrecurrent groups and followed up for 18 months. The difference between two groups was estimated. The patients in the recurrent group were subdivided according to the history of corneal infection and corneal perforation, respectively. The recurrent time in the subgroups was analyzed.
Patients in the recurrent group were more likely to have a history of corneal infection and corneal perforation than that in the nonrecurrent groups. In patients with recurrent Mooren's ulcer, the median time to first recurrence was 130 days in the infection group, 480 days in noninfection group, and 195 days in the perforation group versus 480 days in nonperforation group.
Corneal infection and corneal perforation were associated with early recurrence of Mooren's ulcer. The tailored follow-up schedule should be used for patients with corneal infection and corneal perforation due to the high risk of recurrence.
探讨中国东部地区蚕蚀性角膜溃疡的临床特征，并确定影响蚕蚀性角膜溃疡复发的潜在危险因素。
我们回顾了2005年5月至2014年12月期间诊断为蚕蚀性角膜溃疡的95例患者（100只眼）的病历。将患者分为复发组和非复发组，并随访18个月。评估两组之间的差异。复发组患者分别根据角膜感染史和角膜穿孔史进行细分。分析亚组中的复发时间。
复发组患者比非复发组患者更易有角膜感染史和角膜穿孔史。在复发性蚕蚀性角膜溃疡患者中，感染组首次复发的中位时间为130天，非感染组为480天，穿孔组为195天，而非穿孔组为480天。
角膜感染和角膜穿孔与蚕蚀性角膜溃疡的早期复发有关。由于复发风险高，对于有角膜感染和角膜穿孔的患者应采用定制的随访方案。
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