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新型铂（II）与三（2-羧乙基）膦配合物与DNA及模型脂质膜的相互作用。

Interaction of Newly Platinum(II) with Tris(2-carboxyethyl)phosphine Complex with DNA and Model Lipid Membrane.

作者信息

Pruchnik Hanna, Kral Teresa, Hof Martin

机构信息

Department of Physics and Biophysics, Wrocław University of Environmental and Life Sciences, ul. Norwida 25, 50-375, Wrocław, Poland.

J. Heyrovsky Institute of Physical Chemistry of the ASCR, v.v.i., Dolejškova 2155/3, 182 23, Prague 8, Czech Republic.

出版信息

J Membr Biol. 2017 Oct;250(5):461-470. doi: 10.1007/s00232-017-9972-z. Epub 2017 Jul 25.

DOI:10.1007/s00232-017-9972-z
PMID:28741121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5613069/
Abstract

Structural properties of plasmid DNA and model lipid membrane treated with newly synthesized platinum(II) complex cis-[PtCl{P(CHCHCOOH)}] (cis-DTCEP for short) were studied and compared with effects of anticancer drug cisplatin, cis-[Pt(NH)Cl] (cis-DDP for short). Time Correlated Single Photon Counting Fluorescence Correlation Spectroscopy (TCSPC-FCS) was employed to study interactions between those platinum complexes and DNA. The TCSPC-FCS results suggest that bonding of cis-DTCEP derivative to DNA leads to plasmid strain realignment towards much more compact structure than in the case of cis-DDP. Application of both differential scanning calorimetry and infrared spectroscopy to platinum complexes/DPPC showed that cis-DTCEP slightly increases the phospholipid's main phase transition temperature resulting in decreased fluidity of the model membrane. The newly investigated compound-similarly to cis-DDP-interacts mainly with the DPPC head group however not only by the means of electrostatic forces: this compound probably enters into hydrophilic region of the lipid bilayer and forms hydrogen bonds with COO groups of glycerol and PO group of DPPC.

摘要

研究了新合成的铂（II）配合物顺式-[PtCl{P(CHCHCOOH)}]（简称顺式-DTCEP）处理的质粒DNA和模型脂质膜的结构特性，并与抗癌药物顺铂顺式-[Pt(NH)Cl]（简称顺式-DDP）的作用进行了比较。采用时间相关单光子计数荧光相关光谱法（TCSPC-FCS）研究了这些铂配合物与DNA之间的相互作用。TCSPC-FCS结果表明，顺式-DTCEP衍生物与DNA的结合导致质粒应变重新排列成比顺式-DDP情况下更紧凑的结构。差示扫描量热法和红外光谱法对铂配合物/DPPC的应用表明，顺式-DTCEP略微提高了磷脂的主相变温度，导致模型膜的流动性降低。新研究的化合物与顺式-DDP类似，主要与DPPC头部基团相互作用，但不仅通过静电力：该化合物可能进入脂质双层的亲水区域，并与甘油的COO基团和DPPC的PO基团形成氢键。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2146/5613069/b6073c21e5ea/232_2017_9972_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2146/5613069/e98f28fdd978/232_2017_9972_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2146/5613069/e6edc3ae2c60/232_2017_9972_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2146/5613069/17c8772ba2ec/232_2017_9972_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2146/5613069/b6073c21e5ea/232_2017_9972_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2146/5613069/e98f28fdd978/232_2017_9972_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2146/5613069/e6edc3ae2c60/232_2017_9972_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2146/5613069/17c8772ba2ec/232_2017_9972_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2146/5613069/b6073c21e5ea/232_2017_9972_Fig5_HTML.jpg

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